Obesity and pro-inflammatory mediators are associated with acute kidney injury in patients with A/H1N1 influenza and acute respiratory distress syndrome

Cruz‐Lagunas, Alfredo; Jiménez-Álvarez, Luis Armando; Ramírez, Gustavo; Mendoza-Milla, Criselda; García-Sancho, Ma. Cecilia; Ávila‐Moreno, Federico; Zamudio, Pedro; Urrea, Francisco; Ortiz‐Quintero, Blanca; Campos-Toscuento, Victoria L.; Morán, Juan; Barrera, Aldo; Martínez-Briseño, David; Fernández-Plata, Rosario; Sierra-Vargas, Martha Patricia; Muñoz-Perea, Carolina; Illescas-Flores, Samuel; Bautista, Edgar; Suratt, Benjamin T.; Pérez-Padilla, José Rogelio; Zúñiga, Joaquı́n

doi:10.1016/j.yexmp.2014.10.006

Cited by 12 publications

(11 citation statements)

References 41 publications

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“…In line with the previous studies [ 4 , 13 , 14 , 33 , 36 ], we disclosed that the presence of either infection or AKI was associated with an increased serum PCT level compared to those without the corresponding entity, while the infection had a higher substantial effect than AKI on PCT levels. This finding was clearly shown in the figures presenting with median PCT levels ( Figure S2 and Figure 3 ).…”

Section: Discussionsupporting

confidence: 92%

“…The impact of PCT level on the AKI patients with infection when compared to that on the AKI patients without infection could be found in other investigations [ 12 , 31 ]. However, contradicting results exist, with some studies reporting that the serum PCT level failed to predict AKI occurrence in patients with sepsis [ 4 ] or influenza infection [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…PCT has ever been disclosed as a predictor of AKI in different clinical settings irrespective of the existence of infection [ 4 , 12 ]; nevertheless, contradicting reports appeared in the literature [ 3 , 13 , 14 ]. Besides, the existing knowledge shows that the elevated serum PCT levels in the infection or inflammatory status might be related to the impaired renal clearance of PCT in the chronic kidney disease (CKD) setting [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients

Huang

Lai

Shiao

2020

JCM

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It is unclear whether serum procalcitonin (PCT) levels rise in patients with acute kidney injury (AKI), and it is also unclear whether the elevation of PCT levels in this setting is independent of the existence of infection and impaired renal clearance. We conducted a retrospective study in a regional teaching hospital in Taiwan to evaluate the AKI-predictive ability of serum PCT among critically ill patients. We enrolled 330 patients (mean age, 70.5 ± 16.4 years; 57.0% men) who were admitted to the intensive care unit (ICU) from 1 July 2016, to 31 December 2016, and who had serum PCT measurement performed within 24 h after ICU admission. We used the generalized additive model and generalized linear model to evaluate the association of serum PCT levels and renal function variables. In addition, we used the multivariate logistic regression method to demonstrate serum PCT level as an independent predictor of AKI in both the non-infected patients (odds ratio (OR) = 1.38, 95% confidence interval (CI) = 1.12–1.71, p = 0.003) and the infected patients (OR = 1.23, 95% CI = 1.03–1.46, p = 0.020). In conclusion, serum PCT level at ICU admission is an independent predictor of developing AKI irrespective of infection among critically ill patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients

Huang

Lai

Shiao

2020

JCM

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“…Common childhood illnesses such as asthma, injuries, and joint pain and abdominal issues can be attributed to obesity even at young ages. Furthermore, obesity in the critically ill patients can lead to acute respiratory distress syndrome, acute kidney injury, and other management difficulties [ 27 – 29 ]. Similarly, there is a higher rate of peri- and postoperative complications in obese individuals [ 29 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

Suboptimal Clinical Documentation in Young Children with Severe Obesity at Tertiary Care Centers

Brady

Thaker

Lingren

et al. 2016

International Journal of Pediatrics

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Background and Objectives. The prevalence of severe obesity in children has doubled in the past decade. The objective of this study is to identify the clinical documentation of obesity in young children with a BMI ≥ 99th percentile at two large tertiary care pediatric hospitals. Methods. We used a standardized algorithm utilizing data from electronic health records to identify children with severe early onset obesity (BMI ≥ 99th percentile at age <6 years). We extracted descriptive terms and ICD-9 codes to evaluate documentation of obesity at Boston Children's Hospital and Cincinnati Children's Hospital and Medical Center between 2007 and 2014. Results. A total of 9887 visit records of 2588 children with severe early onset obesity were identified. Based on predefined criteria for documentation of obesity, 21.5% of children (13.5% of visits) had positive documentation, which varied by institution. Documentation in children first seen under 2 years of age was lower than in older children (15% versus 26%). Documentation was significantly higher in girls (29% versus 17%, p < 0.001), African American children (27% versus 19% in whites, p < 0.001), and the obesity focused specialty clinics (70% versus 15% in primary care and 9% in other subspecialty clinics, p < 0.001). Conclusions. There is significant opportunity for improvement in documentation of obesity in young children, even years after the 2007 AAP guidelines for management of obesity.

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“…This condition is most frequent among younger populations (28). Inflammatory mediators such as C-peptide, procalcitonin, serum amyloid A, CRP and others, which are elevated in the early phase of the bacterial infections, frequently present themselves as early complications among patients with influenza, especially those with enlarged body weight as a risk factor (29). According to the study of Vallejos A, acute kidney failure among patients with AH1N1 influenza most frequently manifests within the first week of the development of refractory oliguria, requiring immediate haemodialysis in 10 to 50% of patients as a result of the body's systemic inflammatory response accompanied by the virus, hypotension and shock [30].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Pneumonia on the Course and Outcome in Patients with Seasonal Influzenza

Cvetanovska

Milenovic

Grozdanovski

et al. 2020

Prilozi

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Introduction: Seasonal influenza, although often presented as a mild, self-limiting disease, is frequently accompanied by complications that lead to the development of a severe clinical presentation and a fatal outcome. The most common are respiratory complications, with secondary bacterial pneumonia being the leading cause.Aim: The aim of this study is to determine the impact of pneumonia on the severity of the clinical presentation and outcome in patients with seasonal influenza.Materials and Methods: This research is comparatively group-based and has been conducted at the University Clinic for Infectious Diseases and Febrile Conditions during a three-year period. The analysis consists of 122 adult patients with clinically and laboratory-confirmed influenza. Based on the severity of the clinical picture, the patients are divided into two groups, severe (n=87) and mild (n=35) forms of the disease. The study included demographic, general data, clinical symptoms, and signs as well as complications.Results: Of 122 patients with seasonal influenza, complications were registered among 108(88.52%), with a significantly more frequent emergence among the group with severe influenza 93.1% vs 77.14% (p=0.012). Pneumonia was the most common 98(80.33%) and had a significant effect on disease severity (p=0.002). Complications from the types of ABI 8(6.56%), ARDS 7(5.74%), sepsis 5(4.1%), DIC 4 (3.28%) and otitis 2(1.64%) were reported only in the group with severe influenza. Acute meningoencephalitis was registered among 5(4.1%), gastroenterocolitis among 3(2.46%), and hepatic damage among 14(11.47%) of patients.Conclusion: Pneumonia as the most common complication among patients with seasonal influenza significantly impacts the clinical course and outcome of the illness.

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Obesity and pro-inflammatory mediators are associated with acute kidney injury in patients with A/H1N1 influenza and acute respiratory distress syndrome

Cited by 12 publications

References 41 publications

Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients

Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients

Suboptimal Clinical Documentation in Young Children with Severe Obesity at Tertiary Care Centers

The Impact of Pneumonia on the Course and Outcome in Patients with Seasonal Influzenza

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