Obesity and Premature Loss of Mobility in Two Adolescents with Becker Muscular Dystrophy After HeartMate II Implantation

Hollander, Seth A.; Rizzuto, Sandra; Hollander, Amanda M.; Lin, Aileen; Liu, Esther; Murray, Jenna; Almond, Christopher S.; Rosenthal, David N.

doi:10.1097/mat.0000000000000292

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…There have been reports of increased weight gain following LVAD implantation in muscular dystrophy patients despite an improvement in HF symptoms. This is likely due to an improved appetite coupled with limited exercise tolerance as a result of skeletal myopathy, suggesting that aggressive weight and nutritional management in these patients will also be key to long term successful LVAD support 46 …”

Section: Advanced Hf Therapiesmentioning

confidence: 99%

Is there a future for the use of left ventricular assist devices in Duchenne muscular dystrophy?

Hayes

Nandi

2020

Pediatric Pulmonology

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Duchenne muscular dystrophy (DMD) is the most common form of childhood muscular dystrophy resulting in progressive muscle wasting and weakness. With advancements in respiratory care and the use of glucocorticoids, cardiomyopathy has surpassed respiratory compromise as the leading cause of morbidity and mortality in this patient population. As muscular dystrophy remains a relative contraindication to heart transplantation, end‐stage heart failure management represents a major therapeutic challenge. Long‐term left ventricular assist device (LVAD) therapy has emerged as a promising management strategy to improve the survival and quality of life in DMD cardiomyopathy. Preoperative planning, optimal patient selection, aggressive postoperative rehabilitation, and continued discussion of goals of care are critical considerations for the appropriate use of LVAD in DMD patients with cardiomyopathy.

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Section: Advanced Hf Therapiesmentioning

confidence: 99%

Is there a future for the use of left ventricular assist devices in Duchenne muscular dystrophy?

Hayes

Nandi

2020

Pediatric Pulmonology

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“…15 Since wear and tear owing to the vulnerability of the wire appears to be a major issue, patients who are either more active or are predisposed to damage due to obesity or movement disorders will need to be managed with extra precautions. In one case, driveline fracture occurred due to repeated falls in a patient with Becker muscular dystrophy, 16 highlighting the need for more patient-specific management approaches. Our results indicate that patients with any form of external driveline damage were significantly more likely to be treated with rescue tape and not surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

Driveline damage and repair in continuous‐flow left ventricular assist devices: A systematic review

et al. 2021

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With mounting time on continuous-flow left ventricular assist device (CF-LVAD) support, patients occasionally sustain damage to the device driveline. Outcomes associated with external and internal driveline damage and repair are currently not well documented. We sought to evaluate the outcomes of driveline damage and its repair. Electronic search was performed to identify all relevant studies published over the past 20 years. Fifteen studies were selected for analysis comprising of 55 patients with CF-LVAD dysfunction due to driveline damage. Demographic and perioperative variables along with outcomes including survival rates were extracted and pooled for the systematic review. Most patients (53/55) were supported on HeartMate II LVAD (Abbott Laboratories, Abbott Park, IL). Internal damage was more commonly reported than external damage [69.1% (38/55) vs. 30.9% (17/55), P = .01]. Median time to driveline damage was 1.9 years [IQR 1.0, 2.5]. Most patients presented with a CF-LVAD alarm [94.5% (52/55)] and patients with internal driveline damage had a significantly higher rate of alarm activation compared to that observed for those with external damage [38/38 (100%) vs. 14/17 (82.4%), P = .04]. Patients with internal driveline dysfunction were more likely to experience component wear compared to those with external driveline dysfunction [10/38 (26.3%) vs. 0/17 (0%), P = .05]; 14.5% of patients (8/55) underwent external repair of the driveline, 5.5% (3/55) were treated with rescue tape, and 5.5% (3/55) were placed on an ungrounded cable, indicating a short-to-shield event had occurred. A total of 49.1% of patients (27/55) underwent CF-LVAD exchange, 5.5% (3/55) were weaned off the CF-LVAD to explant, and 5.5% (3/55) underwent emergent heart transplantation. The median length of hospital stay was 12 days [IQR 7, 12] and 30-day mortality rate was 14.5% (8/55). Driveline damage was more commonly reported at an internal location and despite being a well-recognized complication, mortality still appears high. K E Y W O R D S continuous-flow left ventricular assist device driveline, device malfunction, driveline damage, driveline infection, driveline repair, heart transplant 820 | D'ANTONIO eT Al. Patient-level data were extracted from article texts, tables, and figures (ND, EM, and KP). Discrepancies between reviewer opinions were resolved by discussion and consensus. How to cite this article: D'Antonio ND, Maynes EJ, Tatum RT, et al. Driveline damage and repair in continuous-flow left ventricular assist devices: A systematic review.

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Becker muscular dystrophy: case report, review of the literature, and analysis of differentially expressed hub genes

Han

Wang

et al. 2021

Neurol Sci

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Obesity and Premature Loss of Mobility in Two Adolescents with Becker Muscular Dystrophy After HeartMate II Implantation

Cited by 8 publications

References 8 publications

Is there a future for the use of left ventricular assist devices in Duchenne muscular dystrophy?

Is there a future for the use of left ventricular assist devices in Duchenne muscular dystrophy?

Driveline damage and repair in continuous‐flow left ventricular assist devices: A systematic review

Becker muscular dystrophy: case report, review of the literature, and analysis of differentially expressed hub genes

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