Obesity and pain: a systematic review

Chin, Shao-Hua; Huang, Wei-Lin; Akter, Sharmin; Binks, Martin

doi:10.1038/s41366-019-0505-y

Cited by 87 publications

(84 citation statements)

References 65 publications

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“…Excess body fat may play a role in weight-bearing and non-weight-bearing chronic pain conditions. De Jong et al’s (2016) findings that fatty acids enhance the proliferation of CD4+ T cells whose levels correlate with pain intensity in patients with osteoarthritis are consistent with those of other studies, all of which have demonstrated a positive relationship between body weight and chronic pain conditions, including migraine, osteoarthritis, and CLBP (Chin et al, 2019). The reported relationship between lipid dysfunction and migraine status suggests that the BMI–pain link may be independent of the effect of weight on joints and the axial skeleton (Onderwater et al, 2019).…”

Section: Discussionsupporting

confidence: 88%

The Metabolomics of Chronic Pain Conditions: A Systematic Review

Aroke

Powell-Roach

2020

Biological Research For Nursing

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Background: Chronic pain is a significant public health problem in the United States, affecting approximately 100 million people. Yet there is a lack of robust biomarkers for clinical use in chronic pain conditions. Downstream effects of environmental, genomic, and proteomic variations in individuals with chronic pain conditions can be identified and quantified using a metabolomic approach. Aim/Design: The purpose of this systematic review was to examine the literature for reports of potential metabolomic signatures associated with chronic pain conditions. Methods: We searched relevant electronic databases for published studies that used various metabolomic approaches to investigate chronic pain conditions among subjects of all ages. Results: Our search identified a total of 586 articles, 18 of which are included in this review. The reviewed studies used metabolomics to investigate fibromyalgia ( n = 5), osteoarthritis ( n = 4), migraine ( n = 3), musculoskeletal pain ( n = 2), and other chronic pain conditions ( n = 1/condition). Results show that several known and newly identified metabolites differ in individuals with chronic pain conditions compared to those without these conditions. These include amino acids (e.g., glutamine, serine, and phenylalanine) and intermediate products (e.g., succinate, citrate, acetylcarnitine, and N-acetylornithine) of pathways that metabolize various macromolecules. Conclusion: Though more high-quality research is needed, this review provides insights into potential biomarkers for future metabolomics studies in people with chronic pain conditions.

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Section: Discussionsupporting

confidence: 88%

The Metabolomics of Chronic Pain Conditions: A Systematic Review

Aroke

Powell-Roach

2020

Biological Research For Nursing

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“…However, BMI was only related to pain in women. That pain is related to BMI is well documented in general populations, and mechanical impairments, as well as inflammation caused by the presence of adipose tissue are suggested as possible mechanisms for this [63]. In DM1, muscles become atrophied and replaced by fat infiltration, and muscle size is significantly smaller in female as compared to male patients [16].…”

Section: Pain and Gendermentioning

confidence: 98%

Pain in adult myotonic dystrophy type 1: relation to function and gender

et al. 2021

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Background Pain is prevalent in myotonic dystrophy 1 (DM1). This study investigated whether CTG repeat size, disease duration, BMI and motor and psychological function were related to pain in adult patients with DM1, and if there were gender differences regarding intensity and location of pain. Method Cross-sectional design. Pain was investigated in 50 genetically confirmed DM1 patients by combining clinical assessment and self-reports of pain intensity and locations. Pain scoring results were related to CTG size, disease duration, muscle strength, walking capacity measured by 6-min walk test, activity of daily life by Katz ADL Index, respiratory function by Forced Vital Capacity and BMI. In addition, the degree of reported pain was related to Quality of life measured by WHOQOL-BREF; fatigue was measured by Fatigue severity scale; psychological functions were measured by Beck Depression Inventory, Beck Anxiety Inventory, IQ and Autism spectrum Quotient. Results Pain was reported in 84% of the patients and was significantly correlated with CTG size (r = 0.28 p = 0.050), disease duration (r = 0.38 p = 0.007), quality of life (r = − 0.37 p = 0.009), fatigue (r = 0.33 p = 0.02) and forced vital capacity (r = − 0.51, p = 0.005). Significant gender differences, with higher scores for females, were documented. In male subjects the number of pain locations was significantly correlated with quality of life and the autism quotient. In females, pain intensity was significantly correlated with activity, respiratory function and BMI. Conclusions Pain in DM1 was prevalent, with a strong association to lung function and other aspects of the disease. Significant gender differences were present for pain intensity and number of pain locations. How pain was related to other symptoms differed between male and female subjects. Our findings highlight the importance of assessments of pain in DM1 patients.

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“…For example, leptin levels, which signal satiety, have been shown to be particularly elevated in patients with obesity and osteoarthritis 5–7 . As might be expected, those with chronic pain tend to have consistently lower levels of physical activity due to disability and low mood, among other factors 8–11 …”

Section: Introductionmentioning

confidence: 94%

“…[5][6][7] As might be expected, those with chronic pain tend to have consistently lower levels of physical activity due to disability and low mood, among other factors. [8][9][10][11] How patients with obesity and chronic pain respond to weight loss treatments remains unclear. Short-term observational studies suggest that patients with chronic pain do tend to lose weight in a lifestyle modification intervention, and those that lose more weight sometimes have greater pain reduction (along with improved leptin and other markers of metabolic function).…”

mentioning

confidence: 99%

Chronic pain and weight regain in a lifestyle modification trial

Goessl

Befort

Pathak

et al. 2021

Obesity Science & Practice

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Objective: Obesity and chronic pain often co-occur and exert bidirectional influences on one another. How patients with obesity and chronic pain respond to weight loss treatments, however, remains unclear. This study evaluated body weight, physical activity, and diet outcomes in participants with and without chronic pain in a 2-year behavioral weight loss trial.Methods: An analytical cohort of 397 adults was assembled from a Midwestern healthcare system that participated in the larger trial. Participants with chronic pain 1 year prior to, or during, the trial were identified using a validated medical records algorithm. Mixed models were used to estimate changes in outcomes over 24 months.Results: One-third of participants (n ¼ 130) had chronic pain. After adjustment for age, sex, body mass index, and trial arm, weight loss was similar in both groups at 6months (À 7.0 � 0.8 kg with chronic pain vs. À 7.7 � 0.6 kg without). Participants with chronic pain had significantly less weight loss at 24-months relative to those without (À 3.6 � 0.5 vs. À 5.2 � 0.4 kg; p ¼ 0.007). Physical activity, screen time, dietary fat, fruit/vegetable consumption, and sugar-sweetened beverage intake improved similarly in both groups over time. Conclusions: Participants with chronic pain lost ∼33% less weight over 2 years, which was driven by greater weight regain after the first 6 months. Future research should test tailored weight loss maintenance strategies for individuals with chronic pain. K E Y W O R D S dietary assessment, physical activity, weight loss 1 | INTRODUCTION Chronic pain affects over 116 million people, with costs exceeding over $635 billion dollars annually in the United States. 1 Obesity and chronic pain often occur together. Relative to those at a healthy weight, prevalence rates for self-reported daily pain are 68%, 136%, and 254% higher for individuals with class I, class II, and class III obesity, respectively. 2Chronic pain and obesity appear to have bidirectional physiological and behavioral influences on one another. Those with chronic pain tend to release greater amounts of proinflammatory mediators. 3,4 Most notably, interleukin-6 and C-reactive proteinThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Obesity and pain: a systematic review

Cited by 87 publications

References 65 publications

The Metabolomics of Chronic Pain Conditions: A Systematic Review

The Metabolomics of Chronic Pain Conditions: A Systematic Review

Pain in adult myotonic dystrophy type 1: relation to function and gender

Chronic pain and weight regain in a lifestyle modification trial

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