In a multicenter study of patients diagnosed with either multisystem inflammatory syndrome in children (MIS-C) or Kawasaki disease (KD), the authors explored the role of obesity as a comorbidity associated with the clinical course and outcome. 1 The study was motivated by the well-established association of adiposity with inflammation. 2,3 In their analysis of 338 patients with KD and 1429 patients with contemporaneous MIS-C, overweight and obesity were more common in the MIS-C cohort and were associated with a greater likelihood of shock, admission to the intensive care unit (ICU), administration of inotropic medications, and higher blood levels of inflammation markers. The authors found only a single association between obesity and ICU admission for the KD cohort. They concluded that obesity should be considered a risk factor for a more severe clinical course when evaluating children with MIS-C.Certain features of the cohorts are worthy of closer inspection. When dealing with 2 diseases