Obesity and obstructive sleep apnea – Clinical significance of weight loss

Tuomilehto, Henri; Seppä, Juha; Uusitupa, Matti

doi:10.1016/j.smrv.2012.08.002

Cited by 176 publications

(135 citation statements)

References 79 publications

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“…26 In examining why obese patients may have had higher incidence of ARDS, we reviewed ventilator data and found no significant differences in delivered tidal volumes, peak, and plateau pressures between patients with BMI greater and less than 30. We were not able to retrospectively report data on transpulmonary pressures as this was not routinely done at all participating centers.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea, Obesity, and the Development of Acute Respiratory Distress Syndrome

Karnatovskaia

Lee

Bender

et al. 2014

Journal of Clinical Sleep Medicine

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Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea, Obesity, and the Development of Acute Respiratory Distress Syndrome

Karnatovskaia

Lee

Bender

et al. 2014

Journal of Clinical Sleep Medicine

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“…Weight loss is therefore a main goal in the management OSA and all patients should be encouraged to control their weight [Tuomilehto et al 2013]. Unfortunately, most of the diet programs often fail, also because OSA per se determines some metabolic changes that can preclude weight loss.…”

Section: Weight Control and Bariatric Surgerymentioning

confidence: 99%

Obstructive sleep apnoea syndrome and its management

Spicuzza

Caruso

Maria

2015

Therapeutic Advances in Chronic Disease

245

172

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Abstract:Obstructive sleep apnoea (OSA) is a common disorder characterized by repetitive episodes of nocturnal breathing cessation due to upper airway collapse. OSA causes severe symptoms, such as excessive daytime somnolence, and is associated with a significant cardiovascular morbidity and mortality. Different treatment options are now available for an effective management of this disease. After more than three decades from its first use, continuous positive airway pressure (CPAP) is still recognized as the gold standard treatment. Nasal CPAP (nCPAP) is highly effective in controlling symptoms, improving quality of life and reducing the clinical sequelae of sleep apnoea. Other positive airway pressure modalities are available for patients intolerant to CPAP or requiring high levels of positive pressure. Mandibular advancement devices, particularly if custom made, are effective in mild to moderate OSA and provide a viable alternative for patients intolerant to CPAP therapy. The role of surgery remains controversial. Uvulopalatopharyngoplasty is a well established procedure and can be considered when treatment with CPAP has failed, whereas maxillarmandibular surgery can be suggested to patients with a craniofacial malformation. A number of minimally invasive procedures to treat snoring are currently under evaluation. Weight loss improves symptoms and morbidity in all patients with obesity and bariatric surgery is an option in severe obesity. A multidisciplinary approach is necessary for an accurate management of the disease.

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“…Ved obstruktiv søvnapné relatert til overvekt har vektreduksjon gunstig effekt (11). Regelmessig fysisk trening kan også motvirke tilstanden (12).…”

Section: Behandlingunclassified