Obesity and Menopause

Al-Safi, Zain; Polotsky, Alex J.

doi:10.1016/j.bpobgyn.2014.12.002

Cited by 152 publications

(132 citation statements)

References 41 publications

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“…Mid-life is a critical period for many women transitioning into menopause due to changes in body weight, visceral fat accumulation, and cardiometabolic health [3,4,31]. A mechanistic interplay linking oxytocin, hypoestrogenism, and adiposity has been suggested in animal studies showing that: i) ovarian hormone deprivation plays a critical role on oxytocin activity and its expression in the hypothalamic nuclei involved in the control of food intake [25]; ii) hypothalamic and circulating oxytocin are associated with fasting-feeding cycles [32]; iii) weight gain accompanying ovariectomy is blunted by exogenous oxytocin administration [33]; iv) gene knockout of oxytocin and its receptor promotes obesity [15]; v) carriers of mutations related to Sim1 haplo-insufficiency and MAGED1 deficiency harbor low hypothalamic expression of oxytocin and obesity [34,35].…”

Section: Discussionmentioning

confidence: 99%

“…In women, hormone modifications experienced during transition into menopause accompany a shift of body fat distribution from the gynoid to the android type, which is associated with an increase in adipocyte diameter, reduced lipolytic activity, enhanced pro-inflammatory adipokine secretion, and impaired insulin sensitivity [2]. These modifications are critical for the future risk of developing obesity, type 2 diabetes mellitus (T2DM) and cardiometabolic disease [3,4]. …”

Section: Introductionmentioning

confidence: 99%

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Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

et al. 2018

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Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post- than in premenopausal women (NW: p < 0.05; OB: p < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

et al. 2018

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“…The data of Treloar show that this reproductive transition extends for 2 to 8 years before menopause, and that the age at onset of the menopause transition ranges from 39 to 51 years for 95 % of women [34]. Thus, the mean duration of the menopause transition is about 5 years, although both the age at onset and the duration vary widely among individuals, and factors such as smoking, obesity and mood disorders may alter the timing or the duration of the transition period [36][37][38][39].…”

Section: The Menopause Transition (Perimenopause)mentioning

confidence: 99%

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Freeman

2015

womens midlife health

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There is accumulating evidence but no definitive answers about the incidence of depressed mood in the menopause transition and its association with the changing hormonal milieu. While a changing hormonal milieu is the natural condition for all women, only a minority of mid-life women experience debilitating depressive symptoms or clinical depression. This review focuses on associations between depressed mood and the menopause transition, primarily as identified in longitudinal, population-based studies in the past decade. Further aims were to present reported associations between depressed mood and reproductive hormones in the menopause transition as evaluated in the general population and associations of depressive symptoms or clinical depression with menopausal hot flashes or poor sleep in perimenopausal women. There is evidence to support the role of the changing endocrine milieu in the development of depressed mood in the menopause transition, but the contribution of hormones as measured is small. Disentangling the numerous factors that are associated with depression in midlife women is a major challenge for research and for clinical care, where treatments are needed to improve the most distressing menopausal symptoms.

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“…Datos antropométricos como la circunferencia abdominal, la relación cintura y cadera y el IMC fueran evaluados. La medición de la estatura ocurrió con el auxilio del antropómetro SECA 206 en una pared con noventa grados en relación al suelo y sin zócalos con la mujer en la debida posición para la evaluación de este dato; del peso (kg) utilizando una balanza portátil SECA OMEGA 870 digital y del IMC por el producto de la división del peso corporal por la altura al cuadrado (P/E2) ocurriendo la clasificación de las investigadas en eutróficas (18,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)9), sobrepeso (25,0-29,9) y obesidad (30,0-arriba) 12 .…”

Section: Materiales Y Métodosunclassified

Índice de Massa Corporal e fatores associados em mulheres climatéricas

Fonseca

Freitas

Duarte

et al. 2017

eglobal

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Objetivo: Identificar la asociación del índice de masa corporal con factores sociodemográficos, estilo de vida, los hábitos alimentarios, mediciones antropométricas y factores clínicos de mujeres climatéricas asistidos en las Estrategias de Salud de Montes Claros. Metodología: Se trata de un estudio epidemiológico transversal, analítico, con una muestra de 874 mujeres perimenopáusicas seleccionadas por muestreo aleatorio simple. Los datos sociodemográficos, estilo de vida, los hábitos alimentarios y los factores clínicos, obstetricia y ginecología se recogieron a través de cuestionarios estandarizados, además de realizar la evaluación antropométrica. El análisis bivariante se realizó mediante la prueba de chi-cuadrado. Resultados: Los resultados mostraron una alta prevalencia de la obesidad (36,0%) y el sobrepeso (38,1%), así como las asociaciones de índice de masa corporal con el tipo de escuela que asistió (p = 0,009), el tabaquismo (p = 0,023 ), el tratamiento para la pérdida de peso (p = 0,000), las mediciones antropométricas (p = 0,000) y los factores clínicos (p = 0,000). Conclusión: Se concluye que las intervenciones educativas para corregir o mejorar el perfil antropométrico pueden resultar en beneficios para la salud de las mujeres climatéricas, ya que la presencia de la obesidad y el sobrepeso fue alta, y los hábitos de estilo de vida, antropométricas y factores clínicos asociados presentes para que la morbilidad.

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Obesity and Menopause

Cited by 152 publications

References 41 publications

Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Índice de Massa Corporal e fatores associados em mulheres climatéricas

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