Obesity and Male Fertility

Cabler, Stephanie; Agarwal, Ashok; Plessis, Stefan S. du

doi:10.1007/978-1-4614-3335-4_33

Cited by 2 publications

(4 citation statements)

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“…The relationship between obesity and human reproductive indices have been established (Cabler et al 2010). Fertility decline is one of the major consequences of obesity which may result from the generation of ROS leading to testicular oxidative stress, inflammation and apoptosis, with negative consequences on steroidogenesis and spermatogenesis (Du , Cabler et al 2012, Palmer et al 2012. Besides these, impaired testicular energy metabolism may act as a confounding factor in the decline in spermatogenesis observed in obese men (Oliveira et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats

et al. 2020

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Obesity and its accompanying complications predispose to abnormal testicular glucose metabolism, penile erectile dysfunction and subfertility. This study examined the potentials of orlistat in attenuating erectile dysfunction and fertility decline in high-fat diet (HFD)-induced obesity in male rats. Eighteen adult male Sprague-Dawley rats whose weights were between 250-300 g were divided into three groups (n = 6/group), namely; normal control (NC), HFD and HFD + orlistat (10 mg/kg body weight/day co-administered for 12 weeks) (HFD+O). During the 11th and 12th week, mating behaviour and fertility parameters were evaluated, and parameters of glucose metabolism were assessed at the end of the 12th week. Orlistat increased testicular mRNA levels of glucose transporters (Glut1 and Glut3), monocarboxylate transporters (Mct2 and Mct4) and lactate dehydrogenase type C (Ldhc), decreased intratesticular lactate and glucose levels, and LDH activity in obese rats. Furthermore, orlistat increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S- transferase (GST) and glutathione reductase (GR) activities, and total antioxidant capacity (TAC), but decreased malondialdehyde level in the penis of obese rats. Similarly, orlistat improved penile cyclic guanosine monophosphate (cGMP) level, sexual behaviour and fertility outcome in obese rats. Penile cGMP level correlated positively with total mounts and intromissions but correlated negatively with mount/intromission ratio. Orlistat improves fertility potential in obese state by targeting testicular lactate metabolism, penile oxidative stress and sexual behaviour in rats. Therefore, orlistat shows a promising protective effect and may preserve the fertility potential of obese men.

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Section: Discussionmentioning

confidence: 99%

Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats

et al. 2020

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“…Some of the mechanisms that are involved in male infertility due to a fat quantity increase are: changes in the hormones concentration such as reduction of inhibin-B and androgen levels, accompanied by estrogen elevated levels [15]. This is because the total fat, intra-abdominal and subcutaneous is associated with low levels of free and total testosterone in men.…”

Section: Discussionmentioning

confidence: 99%

“…Another consequence of the body fat increase, wa s the scrotal temperature increase [15], since fat is also deposited in the scrotal region, causing an increase in temperature in this region. A slight increase in scrotal temperature can disrupt spermatogenesis and cause fertility problems [39][40][41][42], caused in part by mitochondria degeneration, smooth endoplasmic reticulum dilatation and enlargement of the intercellular spaces between Sertoli cells and spermatids; directly associated with oxidative stress, followed by germ cell apoptosis [43].…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between the Amount of Subcutaneous Fat, Testicular Morphometry, Epididymis and Some Sperm Parameters in Leptonycteris yerbabuenae Bat Before, During and After Mating

Martínez–Coronel¹,

Alicia²,

Arenas‐Ríos³

2015

AVS

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Studies in reproductive age mammals show that the increase in fat content is inversely related to sperm quality in response to a decrease in testosterone levels. In turn the decrease in androgen concentration is related to morphophysiological involution in the testis and epididymis. However, the bat Leptonycteris yerbabuenae increases the body fat content previous the mating period, contrary to what was reported in most mammals. Therefore the aim of this study was to determine the importance of variation in fat content in L. yerbabuenae in relation to testicular and epididymal cycle; and sperm parameters. The results clearly show an increase in the fat content as it approaches the mating season. Also, there is an increase in the size of the testis and epididymis. In the post-mating months, both: fat and testis, decrease and the sperm cells were not presents. Leptonycteris yerbabuenae has a different behaviour to most mammals, accumulate fat while producing, transit and sperm storage could be happening. So, in this model, we must do studies that meet these processes emerging from that reported in other mammals.

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Obesity and Male Fertility

Cited by 2 publications

References 70 publications

Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats

Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats

Relationship Between the Amount of Subcutaneous Fat, Testicular Morphometry, Epididymis and Some Sperm Parameters in Leptonycteris yerbabuenae Bat Before, During and After Mating

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