Obesity and its role in the development of metabolic syndrome in children

This review analyzes the published data on preventive measures to combat the metabolic syndrome (MS) development in children. Recent international studies discuss various risks and territorial differentiation in health status of children with MS. Such databases as PubMed, SCOPUS and Web of Science were used for literature review. It consists of 12 sources, all articles were published between 2020 and 2021. This issue is studied very poorly and requires additional clinical research and identification of new aspects of preventive measures to combat the development of MS in children. The discussion of this topics and further study of the modern aspects of preventive measures of this syndrome are crucial for the timely MS diagnosis and implementation of modern prevention methods due to its wide prevalence, high socio-economic significance, and deteriorating quality of life of children with MS and obesity.

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International View on Preventive Measures to Combat the Metabolic Syndrome Development in Children

Владимирович

Shikaleva

Шавалиев

et al. 2022

Vopr. sovr. pediatr.

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Renal function disorders in children with constitutional-exogenous obesity

Bashkina,

Bezrukova,

Dzhumagaziev

et al. 2024

jour

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To compare blood creatinine levels in children with constitutionally exogenous obesity and in children without obesity. Materials and methods of research. The analysis of serum creatinine levels (Jaffe colorimetric method) was carried out in 162 children with constitutionally exogenous obesity, including overweight children, grade 1–4 obesity and 178 children of the control group who were treated in the Department of endocrinology of the Regional Children's Clinical Hospital of Astrakhan in the age range from one and a half to 17 years. The study period was more than 10 years. The criterion for exclusion from the study was the absence of concomitant pathology of the urinary system. The results and their discussion. When comparing serum creatinine levels in two groups of children (obese and non-obese), a significant increase was found in the group of children with constitutionally exogenous obesity. Thus, creatinine in the blood ≥ 120.0 mmol/l was recorded in 25 children out of 162 examined with constitutionally exogenous obesity and in 3 children out of 178 without obesity (χ 2 = 19.43; p < 0.00001). The highest serum creatinine levels were recorded in children with obesity of 1–2 degrees. Conclusion. Constitutionally exogenous obesity is associated with chronic impairment of nitrogen excretion function of the kidneys.

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Pathology of the gastrointestinal tract in overweight and obese children

Menshchikova,

Kartseva,

Eliseeva

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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Obesity and diseases of the gastrointestinal tract are widespread among the children and have common developmental mechanisms. The article provides a literature review on the relationships between certain pathological conditions of the digestive system (gastroesophageal reflux disease, gastritis, functional intestinal disorders, Crohn’s disease, diverticular disease) in children with overweight and obesity. Excess body weight and obesity can become risk factors for the development of gastrointestinal pathology. The data available in modern literature on changes in the composition of the intestinal and stomach microbiocenosis with increasing body weight are summarized (changes in enterotype, increase in the Firmicutеs/Bacteroides ratio, increase in the number of bacteria Methanobrevibacter, Escherichia coli, Lactobacillus rhamnosus, Lactobacillus delbrueckii and Lactobacillus reuteri). The strains of bacteria that contribute to the anorexigenic effect are considered: Lactobacillus gasseri, some strains of Bifidobacterium, Saccharomyces, Streptococcus and Enterococcus. The pathogenetic aspects of obesity and overweight caused by microbiota are presented: activation of lipid synthesis, breakdown of polysaccharides, absorption of mono- and disaccharides, development of metabolic endotoxemia, etc. Features of the functioning of the autonomic nervous system in obesity in children are presented, indicating the predominance of the hypersympathicotonic variant of autonomic reactivity.

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Obesity and its role in the development of metabolic syndrome in children

Cited by 3 publications

References 14 publications

International View on Preventive Measures to Combat the Metabolic Syndrome Development in Children

International View on Preventive Measures to Combat the Metabolic Syndrome Development in Children

Renal function disorders in children with constitutional-exogenous obesity

Pathology of the gastrointestinal tract in overweight and obese children

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