Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry

Abstract

BackgroundThe aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.MethodsData were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.ResultsData were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m2) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.ConclusionObesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.

Klinefelter Syndrome and Metabolic Disorder

“…Considering this KNHANES data from the general population, prevalence of obesity in Korean patients with Klinefelter syndrome is greatly increased, as found in previous studies [410]. Additionally, in the current study, testosterone levels were negatively correlated with BMI and fasting glucose, which agrees with previous findings [1410]. Epidemiological studies on Klinefelter syndrome have been conducted mostly in Western cohorts, particularly in the British and the Danish populations [4].…”

“…Based on the data acquired from the Korea National Health and Nutrition Examination Survey (KNHANES) in 2011, the prevalence of obesity (defined by BMI ≥25 kg/m 2 ) in the Korean general population was 32.0% [11]. Considering this KNHANES data from the general population, prevalence of obesity in Korean patients with Klinefelter syndrome is greatly increased, as found in previous studies [410]. Additionally, in the current study, testosterone levels were negatively correlated with BMI and fasting glucose, which agrees with previous findings [1410].…”

“…Epidemiological studies on Klinefelter syndrome have been conducted mostly in Western cohorts, particularly in the British and the Danish populations [4]. The present study by Han et al [10] with a large sample size was conducted in Asian patients, which make the findings in this study more valuable.…”

“…In this issue of Endocrinology and Metabolism , Han et al [10] found that the prevalence of obesity (defined by body mass index [BMI] ≥25 kg/m 2 ) in Korean men with Klinefelter syndrome was 42.6% (160 of 376 patients). Based on the data acquired from the Korea National Health and Nutrition Examination Survey (KNHANES) in 2011, the prevalence of obesity (defined by BMI ≥25 kg/m 2 ) in the Korean general population was 32.0% [11].…”

Klinefelter Syndrome with Morbid Obesity Before Bariatric Surgery: A Case Report

“…Recent studies report KS is associated with abdominal obesity and increased risk of metabolic syndrome. Although patients with KS have abdominal adiposity, their BMI is normal and decrease in muscle mass, increase in body fat and change in body composition are common in this patients (4,8). Testosterone treatment cause Decrease in fat mass.…”