Obesity and hyperglycemia as a bad prognosis factor for recurrence and survival in colon cancer

A systematic review and meta-analysis assessing the impact of body mass index on long-term survival outcomes after surgery for colorectal cancer

“…Another source of heterogeneity may be the variation in the period of median follow-up. Some studies in the review included all stages of colorectal cancer, while others restricted their inclusion criteria to a specific stage [33,37,41]. Moreover, survival outcomes in obese patients have been shown to differ in relation to the stage of colorectal cancer [63,65].…”

The prognostic role of fasting plasma glucose levels on survival in advanced colorectal cancer patients with type II diabetes mellitus: a retrospective cohort study

“…It can also induce the migration and invasion of cancer cells and induce the resistance of cancer cells to chemotherapy to affect the survival of patients (14). Some current survival analysis studies have shown the poor prognosis of hyperglycemia in patients with CRC (15)(16)(17)(18). The subjects of these studies on blood glucose levels mostly comprised patients with stage I-III CRC.…”

A guideline for the outpatient management of glycaemic control in people with cancer

“…Data are also emerging to suggest that hyperglycaemia may be associated with worse overall survival (OS) and increased risk of cancer recurrence in a number of cancer subtypes, including both solid and haematological malignancies. 4,[6][7][8][9][10][11][12][13][14][15] One of the largest of these reviewed 12 retrospective studies comprising of 9,872 people with cancer and without known diabetes. Individuals with hyperglycaemia were found to have a significantly worse disease-free survival (hazard ratio [HR] 1.98, 95% confidence interval [CI] 1.20-3.27) compared with those with normo-glycaemia, as well as worse OS (HR 2.05, 95% CI 1.67-2.551).…”

“…The evidence was demonstrated to be most robust for breast cancer, intrahepatic cholangiocarcinoma, colorectal cancer and endometrial cancer, although most included studies demonstrated substantial heterogeneity. Data are also emerging to suggest that hyperglycaemia may be associated with worse overall survival (OS) and increased risk of cancer recurrence in a number of cancer subtypes, including both solid and haematological malignancies 4,6–15 . One of the largest of these reviewed 12 retrospective studies comprising of 9,872 people with cancer and without known diabetes.…”