Obesity and hypercholesterolemia in patients with prolactinomas: Could DHEA-S and growth hormone be the missing link?

Perić, Božidar; Kruljac, Ivan; Šundalić, Sara; Pećina, Hrvoje Ivan; Jović, Andrijana; Štefanović, Mario; Butorac, Dražan; Vrkljan, Milan

doi:10.3109/07435800.2015.1135444

Cited by 27 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study in which non-functional pituitary adenomas and prolactinoma were evaluated, BMI was reported to be significantly higher in the prolactinoma group. That group also had diminished growth hormone and insulin-like growth factor-1 levels (22). It has been shown that the modulatory effect of PRL may influence fat tissue and PRL changes body weight and composition.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren

Ergür

Isguven

et al. 2019

Jcrpe

View full text Add to dashboard Cite

Objective: We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases of pediatric hyperprolactinemia in a large multicenter study. Methods: We reviewed the records of 233 hyperprolactinemic patients, under 18 years of age, who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia and idiopathic hyperprolactinemia. Complaints of the patients, their mode of treatment (medication and/or surgery) and outcomes were evaluated in detail. Results: The mean age of the patients with hyperprolactinemia was 14.5 years, and 88.4% were females. In terms of etiology, microadenomas were observed in 32.6%, macroadenomas in 27%, idiopathic hyperprolactinemia in 22.7% and drug-induced hyperprolactinemia in 6.4%. Other causes of hyperprolactinemia were defined in 11.3%. Common complaints in females (n=206) were sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea and weight gain, whereas headache, gynecomastia, short stature and blurred vision were common in males (n=27). Median prolactin levels were 93.15 ng/mL, 241.8 ng/mL, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for microadenomas, macroadenomas, idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and other causes of hyperprolactinemia, respectively. Of 172 patients with hyperprolactinemia, 77.3% were treated with cabergoline and 13.4% with bromocriptine. 20.1% of the patients with pituitary adenomas underwent pituitary surgery. Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren

Ergür

Isguven

et al. 2019

Jcrpe

View full text Add to dashboard Cite

show abstract

“…What's more glyburide increased PRL secretion from anterior pituitary through inhibition of somatostatin (endogenous inhibitor of prolactin). [33]…”

Section: Discussionmentioning

confidence: 99%

Metabolic profile and prolactin serum levels in men with type 2 diabetes mellitus: Old-new rubric

Al-Nami

Al-Kuraishy

Al-Gareeb

et al. 2019

Int J Crit Illn Inj Sci

View full text Add to dashboard Cite

Background:Prolactin (PRL) is involved in the regulation of glucose metabolism since high PRL serum levels are associated with low incidence of type 2 diabetes mellitus (T2DM). Therefore, the aim of the present study was to assess the metabolic effects of PRL on glucose homeostasis in men with T2DM.Methods:Eighty male patients with T2DM compared with 25 male healthy controls matched with patients for age and weight were divided into four groups: Group (A): patients with T2DM on metformin (n = 29), Group (B): patients with T2DM on glyburide (n = 30), Group (C): patients with T2DM on glyburide plus metformin (n = 21), and Group (D): healthy male subjects as control (n = 25). Body mass index (BMI) and blood pressure measurements were determined. Fasting blood glucose (FBG), glycated hemoglobin, total cholesterol, triglyceride (TG), high-density lipoprotein, low-density lipoprotein, atherogenic index, fasting serum insulin, insulin resistance (IR), and β-cell function of the pancreas were determined by homeostatic model assessment-2 (HOMA-IR). Furthermore, C-reactive protein and PRL serum level were determined in patients with T2DM and healthy control men.Results:BMI of T2DM patients was higher as compared with control (P = 0.003). Combination therapy (glyburide plus metformin) in patients with T2DM showed better effect on most of glycemic indices and lipid profile than glyburide or metformin monotherapy (P < 0.05). PRL serum level was higher in patients with T2DM as compared with control (P = 0.001). PRL serum level was high in glyburide-treated patients as compared with metformin-treated patients (P = 0.002).Conclusion:This study concludes that elevated PRL serum level in patients with T2DM is associated with diabetic complications. Diabetic pharmacotherapy mainly metformin reduced PRL serum level in patients with T2DM through amelioration of IR.

show abstract

“…The dyslipidaemia, glucose intolerance, hyperinsulinaemia and insulin resistance described in these situations have been improved in some cases by lowering prolactin levels with dopamine agonist drugs. 23,25,32,33,35,36,43,44 Metabolic pathological aspects of prolactin excess in humans are also exemplified by the association between the PRL locus BAT, probably related to increased NPY levels in the DMH 95 as a result of the known regulation of BAT activity in this brain region. 114…”

Section: Prol Ac Tin and Ad Ip Os E Tissuementioning

confidence: 99%

“…28 Pathological hyperprolactinaemia resulting from pituitary tumours or chronic blockade of dopamine receptors during psychiatric medication has been associated with metabolic alterations. In patients with prolactinomas, predisposition to obesity, 23,25,[30][31][32][33][34] dyslipidaemia, [35][36][37] high cholesterol levels, 33 non-alcoholic fatty liver disease (NAFLD), 34 metabolic syndrome, 38 hyperinsulinaemia, [37][38][39] insulin resistance 35,[39][40][41] and intolerance to glucose have been described. Notably, not all metabolic manifestations are present in every cohort of patients, revealing a selective predisposition of patients to different aspects of metabolic disturbances associated with prolactin.…”

mentioning

confidence: 99%

Metabolic functions of prolactin: Physiological and pathological aspects

Lopez‐Vicchi

Winne

Brie

et al. 2020

J Neuroendocrinology

View full text Add to dashboard Cite

Prolactin is a pleiotropic hormone that is named after its major role in lactation in mammals. Alongside this role in milk production, prolactin has been implicated in a wide range of functions, including regulating aspects of the immune system, the reproductive system and metabolism. The wide scope of functions for prolactin is considered to converge during pregnancy and lactation, when prolactin concentrations are high, and it is hypothesised that prolactin has a role not only in milk production, but also as a signal to many of the systems in the body driving maternal adaptations to meet the demands of these physiologically challenging states. 1 Although high prolactin concentrations are appropriate during pregnancy and lactation, 1-3 there are many pathological conditions of hyperprolactinaemia, such as prolactin-secreting tumours and dopamine receptor antagonising drug treatments, 4 and these pathologically high prolactin concentrations are likely to impact on many different aspects of physiology and lead to metabolic dysfunction. The focus of this review is to examine the effects of prolactin on metabolism and energy homeostasis in both the physiological and pathological states of hyperprolactinaemia. Prolactin is secreted by lactotroph cells and, unlike other hormones secreted by the anterior pituitary, its secretion is regulated

show abstract

Obesity and hypercholesterolemia in patients with prolactinomas: Could DHEA-S and growth hormone be the missing link?

Cited by 27 publications

References 21 publications

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Metabolic profile and prolactin serum levels in men with type 2 diabetes mellitus: Old-new rubric

Metabolic functions of prolactin: Physiological and pathological aspects

Contact Info

Product

Resources

About