Obesity and gestational diabetes in pregnancy: an evolving epidemic

Ogburn, Paul L.

doi:10.1515/jpm-2016-0117

Cited by 3 publications

(2 citation statements)

References 11 publications

(11 reference statements)

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“…Insulin resistance increases in early pregnancy, while glucose intolerance and fetal overgrowth occurs in late pregnancy. Overweight and obesity before pregnancy could increase the risk of gestational diabetes mellitus and cesarean section rate (13). A study in Croatia noted that pregnant women with obesity had a higher risk of preterm delivery, induced labor and cesarean section than normal pregnant women (14).…”

Section: Discussionmentioning

confidence: 99%

“…GDM is associated with multiple delivery complications and perinatal outcomes, such as hypertriglyceridemia preterm rupture of membranes, preterm delivery, postpartum hemorrhage, fetal distress, etc. (P<0.05) (13). A prospective cohort study of 694 pregnant women in Ethiopia found that compared to normal pregnant women, those with GDM had a higher risk of adverse pregnancy outcomes (OR: 1.58; 95% CI: 1.22-2.04) and higher incidence of gestational hypertension, preterm rupture of membranes, prenatal hemorrhage, and postpartum hemorrhage (25).…”

Section: Discussionmentioning

confidence: 99%

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Effects of obesity indices/GDM on the pregnancy outcomes in Chinese women: A retrospective cohort study

Song

Chen

et al. 2022

Front. Endocrinol.

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ObjectiveTo analyze pregnancy complications and outcomes of mothers with obesity or gestational diabetes mellitus (GDM).Methods15065 mothers were categorized into four and three groups by pre-pregnancy body mass index (preBMI) and abdominal circumference (AC), respectively, or divided into GDM or non-GDM groups. Logistic regression analysis was utilized to identify independent factors associated with pregnancy complications and outcomes.ResultsThe overweight and obesity groups accounted for 16.0% and 4.0% of the total population, respectively. GDM incidence rate was 12.3%. The overweight and obesity groups (pre-pregnancy body mass index [preBMI] ≥ 24 kg/m2) were at higher risks for GDM, hypertensive disorders of pregnancy (HDP), gestational proteinuria, postpartum hemorrhage, preterm delivery, fetal malformation or stillbirth, neonatal asphyxia, large for gestational age (LGA), shoulder dystocia, and increased cesarean section rate. Similar results were obtained with AC grouping. GDM pregnant women had higher risks of HDP, preterm delivery, small for gestational age (SGA), LGA, and increased cesarean section rate.ConclusionPeople with obesity had a higher risk of adverse pregnancy outcomes. The recommended preBMI is 19.2-22.7 kg/m2. The recommended AC at 11-13+6 gestational weeks is 74.0-84.0 cm, and that value in normal preBMI is 74.0-82.0 cm.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of obesity indices/GDM on the pregnancy outcomes in Chinese women: A retrospective cohort study

Song

Chen

et al. 2022

Front. Endocrinol.

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Relación entre el índice de masa corporal materno y los resultados adversos en el embarazo: Revisión sistemática de la literatura

et al. 2020

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La creciente incidencia de la obesidad a nivel mundial, ha hecho de esta uno de los principales problemas de Salud Pública durante la gestación, al aumentar las comorbilidades maternas y perinatales y alterar el curso normal del embarazo, que pasa a denominarse embarazo de alto riesgo. El objetivo de este estudio fue determinar la asociación entre el índice de masa corporal y las complicaciones que se producen en el embarazo. Se ha efectuado una revisión sistemática siguiendo los criterios del protocolo PRISMA. La búsqueda se realizó en las bases de datos PubMed, Scopus y Cinahl entre los meses de enero y mayo de 2019. Las mujeres obesas o con sobrepeso mostraron más complicaciones en el embarazo, como diabetes mellitus gestacional, preeclampsia, parto pretérmino, cesárea, niños macrosómicos y una mayor tasa de abortos que las gestantes de peso normal. Las intervenciones de educación sanitaria durante el embarazo mejoraron la condición física de las gestantes, pero no redujeron las complicaciones. Se concluye que el sobrepeso y la obesidad se asocian con importantes complicaciones durante la gestación y durante el parto.

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Human Gut Microbiota and Obesity During Development

Cerdó¹,

Ruiz²,

Campoy³

2017

Adiposity - Omics and Molecular Understanding

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Obesity, particularly in children and adolescents, has become a signiicant public health problem that has reached "epidemic" status worldwide. The etiology of obesity is complex and involves lifestyle factors that are challenging to modify. The intestinal microbiota contribute to protection against pathogens, maturation of the immune system, and metabolic welfare of the host but, under some circumstances, can contribute to the pathogenesis of certain diseases. Over the last decade, novel evidence from animal and human studies has identiied associations between human intestinal bacteria and host metabolism and obesity. Infancy is a critical period in the development of the gut microbiota: initial colonization is inluenced not only by a number of early-life exposures, including birth mode, infant nutrition, or antibiotic use, but also by maternal factors during pregnancy, including maternal BMI, nutrition, gut microbial composition, and drug exposure, among others. Thus, an adequate nutritional and microbial environment during the perinatal period and early life may provide windows of opportunity to reduce the risk of obesity and overweight in our children by using targeted strategies aimed to modulate the gut microbiota during early life.

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Obesity and gestational diabetes in pregnancy: an evolving epidemic

Cited by 3 publications

References 11 publications

Effects of obesity indices/GDM on the pregnancy outcomes in Chinese women: A retrospective cohort study

Effects of obesity indices/GDM on the pregnancy outcomes in Chinese women: A retrospective cohort study

Relación entre el índice de masa corporal materno y los resultados adversos en el embarazo: Revisión sistemática de la literatura

Human Gut Microbiota and Obesity During Development

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