Obesity and female malignancies

Benedetto, Chiara; Salvagno, Francesca; Canuto, Emilie Marion; Gennarelli, Gianluca

doi:10.1016/j.bpobgyn.2015.01.003

Cited by 37 publications

(39 citation statements)

References 91 publications

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“…Chemoresistance has been shown to be the main obstacle for radical treatments of cervical cancer and other types of malignances (Benedetto et al, 2015). Accumulating studies have indicated that autophagy plays an important role in the chemo-resistance of cancers (MartinezOutschoorn et al, 2011;Nencioni et al, 2013;Chang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

2015

Genet. Mol. Res.

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ABSTRACT. Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, "eating of self", has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy in cisplatinsensitivity of CC cells via blockage of cisplatin-induced autophagy. The results demonstrated that cisplatin induces autophagy in CC HeLa cells via upregulating the formation of autophagic vesicle, promoting the conversion of LC-I to LC-II, and increasing the expression of autophagy-related gene 7 (Atg-7). On the other hand, the autophagy inhibitor, 3MA, downregulated cisplatin-induced formation of autophagic vesicles, reduced the conversion of LC-I to LC-II, and decreased Atg-7 expression. Moreover, 3MA reversed the reduction in cellular viability and induction of apoptosis by cisplatin in HeLa cells. Our results imply that autophagy blockage may play a key role in the chemosensitivity of cervical cancers.

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Section: Discussionmentioning

confidence: 99%

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

2015

Genet. Mol. Res.

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“…It is estimated that 20% of cancer cases are related to obesity, and obese cancer patients have a worse prognosis 12 . Women with morbid obesity (body mass index ≥ 35) and cervical cancer were proven to have a higher risk of death (hazard ratio = 1.26, 95% CI, 1.1-1.45) when compared to women with cervical cancer and a normal weight 13 . Excess body fat plays a role in cancer recurrence and patient survival.…”

Section: Nutrient Recommendations For Patients With Comorbidities Obementioning

confidence: 99%

“…In the particular case of cervical cancer, the use of high-energy radiation to the middle pelvis without overdosing peripheral healthy tissues represents a technical challenge. For these reasons, it is of utmost importance to implement an adequate nutritional treatment for obese patients with cervical cancer 12,13 . Level of evidence B, strength of recommendation 1.…”

Section: Nutrient Recommendations For Patients With Comorbidities Obementioning

confidence: 99%

Nutrient Recommendations for Cancer Patients Treated with Pelvic Radiotherapy, with or without Comorbidities

Castro-Eguiluz

Leyva-Islas

Luvian-Morales

et al. 2018

RIC

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Radiotherapy is one of the main treatment options used in pelvic cancers. Ionizing radiation induces damage to surrounding tissues, resulting in disruption of normal physiological functions and symptoms such as diarrhea, tenesmus, incontinence, and rectal bleeding, which can all significantly alter the patient's quality of life. These patients are at increased risk of developing protein-calorie malnutrition and micronutrient deficiencies. Therefore, designing a proper nutritional intervention plan, with an optimal proportion of protein, fat, and carbohydrates, is required to reduce or even reverse the patients' poor nutritional status, increase their tolerance and response to oncology treatment, decrease the rate of complications and improve their quality of life. The aim of this review was to establish a nutritional plan that includes recommendations on macronutrient proportions and micronutrient intake in patients receiving pelvic radiotherapy. The following nutritional plan has been recommended in the literature: Energy: 28-31 kcal/kg/day, using the Harris-Benedict formula adjusted for body weight in obese patients; protein: 20-30%; fat: 30-40%; and carbohydrates: 40-50%. The maintenance of adequate levels of Vitamin D, Vitamin E, Vitamin A, calcium, magnesium, thiamin, riboflavin, and niacin must be emphasized. Physical activity must also be increased to maintain muscle mass. Nutrient requirements must be established in an integral manner, considering the patient's age, nutritional status, and the presence of comorbidities. Unnecessary dietary restrictions should be avoided to ensure an adequate nutritional status.

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“…Obesity is associated with the peripheral conversion of androstenedione to estrone which is an etiological factor. 2 The increase in numbers is likely to be associated with a differing morbidity profile. Minimally invasive surgery in these women has already resulted in shorter length of stay and less complications.…”

Section: Introductionmentioning

confidence: 99%

The effect of obesity on clinical and economic outcomes in robotic endometrial cancer surgery

Ind

Marshall

Hacking

et al. 2017

RSRR

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Abstract:The aim of this study was to compare the financial and clinical outcomes in roboticassisted laparoscopic surgery for primary endometrial cancer between obese and nonobese women. The hospital finance department assessed the total admission costs for robotic surgery for endometrial cancer in 54 women. This included a subanalysis for costs over nine areas (ward and clinics, drugs and pharmacy, medical staff, theaters, blood products, imaging, pathology, rehabilitation therapy, and high dependency costs). Furthermore, a prospective collection of morbidity and surgical outcome data was performed. The study group included 21 nonobese and 33 obese women (body mass index >30). Obese women were more likely to stay for more than one night in hospital (20/ ). There were six Clavien-Dindo grade II complications in the obese group and two in the nonobese group. The average overall costs were £1,852 greater (95% CI £431-£3,277, P=0.012) in the obese group. Diabetes and hypertension were associated with increased costs, but obesity was the only independent variable. In conclusion, greater resource should be allocated to obese women undergoing primary surgery for endometrial cancer.

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Obesity and female malignancies

Cited by 37 publications

References 91 publications

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

Nutrient Recommendations for Cancer Patients Treated with Pelvic Radiotherapy, with or without Comorbidities

The effect of obesity on clinical and economic outcomes in robotic endometrial cancer surgery

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