Obesity and female infertility: potential mediators of obesity's impact

Broughton, Darcy E.; Moley, Kelle H.

doi:10.1016/j.fertnstert.2017.01.017

Cited by 577 publications

(471 citation statements)

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“…In fact, both clinical and experimental data support that obesity is negatively correlated with normal reproductive function. Notwithstanding, the negative impact of increased body adiposity for female reproductive potential has long been recognized; more recently, the hazard effects on male reproductive function have also been disclosed . Indeed, nearly 20% of the subfertility and infertility in males can be directly attributed to overweight and obesity .…”

Section: Introductionmentioning

confidence: 99%

Obesity and male hypogonadism: Tales of a vicious cycle

et al. 2019

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Summary Obesity prevalence, particularly in children and young adults, is perilously increasing worldwide foreseeing serious negative health impacts in the future to come. Obesity is linked to impaired male gonadal function and is currently a major cause of hypogonadism. Besides signs and symptoms directly derived from decreased circulating testosterone levels, males with obesity also present poor fertility outcomes, further evidencing the parallelism between obesity and male reproductive function. In addition, males with androgen deficiency also exhibit increased fat accumulation and reduced muscle and mineral bone mass. Thus, compelling evidence highlights a vicious cycle where male hypogonadism can lead to increased adiposity, while obesity can be a cause for male hypogonadism. On the opposite direction, sustained weight loss can attain amelioration of male gonadal function. In this scenario, a thorough evaluation of gonadal function in men with obesity is crucial to dissect the causes from the consequences in order to target clinical interventions towards maximized improvement of reproductive health. This review will address the causes and consequences of the bidirectional relationship between obesity and hypogonadism, highlighting the implicit male reproductive repercussions.

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Section: Introductionmentioning

confidence: 99%

Obesity and male hypogonadism: Tales of a vicious cycle

et al. 2019

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“…The identified decrease in child benefit is attributable to a decreased birth rate among obese women, as obesity has shown also to be associated with complications in pregnancy and reproductive complications and disorders [7,47]. The decrease in early retirement benefit can be explained by a reduced capacity of work at a younger age than the early retirement age limit.…”

Section: Discussionmentioning

confidence: 99%

The Socioeconomic Burden of Obesity

Kjellberg¹,

Larsen

Ibsen

et al. 2017

Obes Facts

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Objective: To evaluate the socioeconomic impact of obesity by estimating the direct and indirect costs associated with obesity in Denmark, based on individual level data. Methods: Costs were assessed for different BMI groups, and the relative risks for change in direct and indirect costs per BMI point above 30 were estimated. A fourth analysis estimated the odds ratio for comorbidities per BMI point above 30. Individual data on income, social transfer payments, healthcare costs and diagnoses were retrieved from national registries. Results: One BMI point above 30 was associated with a 2% decrease in income, a 3% increase in social transfer payments, and a 4% increase in healthcare costs. In absolute numbers, income contributed to most of the total economic burden. One BMI point above 30 was also associated with increased comorbidity, which explains the increase in both direct and indirect costs. Conclusion: Obesity is associated with increased comorbidity, giving rise to an increase in both direct and indirect costs. Especially income is affected, which emphasizes the importance of including both measures when evaluating the total socioeconomic burden of obesity. Our findings draw attention to the potential for saving public resources and preventing loss of income by preventing obesity.

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“…Obese women tend to experience more menstrual irregularity than nonobese women, resulting in a higher rate of female infertility [3]. In previous data from the Korea National Health and Nutrition Examination Survey, metabolic syndrome was significantly associated with menstrual irregularity in reproductive-age women [4].…”

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confidence: 99%

“…Ovulatory dysfunction takes place in obese women due to dysregulation of the hypothalamic-pituitary-ovarian axis [3]. Adiposity alters oocyte quality and endometrial receptivity via excess free fatty acids and adipokines [35].…”

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confidence: 99%