Obesity and Dyslipidemia: A Review of Current Evidence

Vekić, Jelena; Stefanović, Aleksandra; Zeljković, Aleksandra

doi:10.1007/s13679-023-00518-z

Cited by 25 publications

(7 citation statements)

References 146 publications

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“…While BMI has historically been recommended as a key index for the estimation of dyslipidemia, it has now been established that BMI has limitations accurately assessing body fatness. This is because BMI does not consider factors related to body size and abdominal obesity, which can significantly influence lipid profile [2]. Reports indicate that BMI fails to differentiate between weight associated with increased muscles and uneven excess fat accumulation.…”

Section: Gonadotropicmentioning

confidence: 99%

Role of newly designed anthropometric parameters in assessment of gonadotropic hormones and lipid fractions in females

Quddus,

Sultan,

Shoaib

2023

TSFJB

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This study investigated the predictive capabilities of newly designed anthropometric indices (Body Shape Index [ABSI], Body Roundness Index [BRI], and Visceral Adiposity Index [VAI]) for identifying abnormal levels of gonadotropic hormones (Follicle Stimulating Hormone [FSH] and Luteinizing Hormone [LH]) and abnormal lipid profiles in 289 females residing in the Lahore area. FSH and LH levels were measured using commercially available kits employing the chemiluminescent microparticle immunoassay (CMIA). The lipid profile (i.e., Total cholesterol [TC], Triglyceride [TG], and High-density lipoprotein cholesterol [HDL-C]) was assessed using the colorimetric method, while Low-Density Lipoprotein Cholesterol (LDL-C) was calculated mathematically. Standardized formulas were used to calculate the anthropometric indices (ABSI, BRI, and VAI) based on weight (kg), height (m), and waist circumference (cm). The results revealed that low HDL-C levels constituted the most common lipid abnormality within the studied population. The trends of ABSI, BRI, and VAI did not exhibit significant differences between FSH and LH-based groups. Additionally, non-significant results and receiver operating characteristic (ROC) curve analysis confirmed weak predictive capabilities for identifying abnormal FSH and LH levels. This study concludes that ABSI, BRI, and VAI are not strong predictors of abnormal gonadotropic hormone levels.

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Section: Gonadotropicmentioning

confidence: 99%

Role of newly designed anthropometric parameters in assessment of gonadotropic hormones and lipid fractions in females

Quddus,

Sultan,

Shoaib

2023

TSFJB

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“…Numerous investigations have indicated an association between DED and DLP (1,5,(9)(10)(11)(12)(13). The studies propose that lipid composition changes may impact the tear lm's stability and contribute to the onset of DED (14).…”

Section: Introductionmentioning

confidence: 99%

The assessment of leukocyte systemic inflammation index ratios in dyslipidemia patients with dry eye disease

Alhalwani,

Hafez,

Jambi

et al. 2024

Preprint

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Background One of the many adverse effects of dyslipidemia (DLP) is dry eye disease (DED), which is brought on by metabolic syndrome and increases inflammation. This research aimed to assess the leukocyte systemic inflammation index ratios in DLP with DED (DED-DLP) as potential biomarkers of systemic inflammation. Methods Several sets of blood biomarkers were studied. There were specific leukocyte profile parameters (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte*platelet ratio (NLPR)); the lipid profile (levels of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides): and an inflammation marker (C-reactive protein (CRP)). These were evaluated in 32 patients with DED-DLP (study group) and 52 subjects without DLP (control group). Results The study group had significantly greater levels of monocytes and CRP than did the control group (p = 0.024 and 0.049, respectively). A negative correlation with a statistically significant difference between HDL and NLPR (p = 0.007; r=-0.428) and a negative correlation with a statistically significant difference between albumin levels and PLR values (p = 0.008; r=-0.420) were seen as predictors of DED-DLP. Conclusion Individuals with DLP are more likely than those without the condition to experience DED because the levels of their leukocyte systemic inflammation index ratios reflect the seriousness of systemic inflammation. The study found that CRP and NLPR levels might be helpful as predictors of the likelihood of the development of DED by DLP patients. Additional research is needed to determine the additive contribution played by leukocytes and the significance of NLR, PLR, and MLR.

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“…Hyperlipidemia is considered as increased total cholesterol (TC) levels while dyslipidemia is imbalanced levels of Low-Density Lipoprotein (LDL), Triglycerides (TG), Very Low Density Lipoproteins (v-LDL) and High-Density Lipoprotein (HDL) levels in blood [ 1 ]. Dyslipidemia and hyperlipidemia are considered as major public health concerns as they are leading causes of vascular diseases [ 2 ]. Obesity, insulin resistance, sedentary lifestyles and high-fat diets consumption play a major role in pathophysiology of dyslipidemia [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

From plate to profile: investigating the influence of dietary habits and inactive lifestyle on lipid profile in medical students at clerkship

Haider,

Abbas,

Arif

et al. 2024

BMC Nutr

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Background Dietary habits have a strong association with body lipid levels and hyperlipidemia increases the risk of cardiovascular and metabolic diseases. Dietary habits have been a major concern among medical students due to busy schedules and demanding tasks. This study was designed to know the dietary habits and lifestyle of medical students and its association with their lipid profile. Methods We recruited 120 medical students at clerkship of the age of 18 and above. Weekly dietary habits were evaluated by an 18-item questionnaire. Five ml blood was drawn from the students and lipid profiles were measured at Dow Diagnostic Research and Reference Laboratory (DDRRL). Data was analyzed by SPSS V.22. Results We found 70% of students were not involved in any physical activity throughout the week. Only 15.83% were following a regular diet plan. 65% of students were eating junk food for more than 3 days a week in their weekly diet. Moreover, 19.2%, 39.2%, 32.5%, and 25.84% of students were having their total cholesterol, triglycerides, HDL, and LDL levels above the optimum ranges respectively which were frequently found in students of final year (p < 0.05). There was high total cholesterol and LDL in males as compared to females (p value < 0.05). Total cholesterol and LDL were associated with skipped meal, use of junk food and carbonated drinks for more than 3 days a week (p < 0.05). Conclusion There was a notable number of students with poor dietary habits, inactive lifestyle and lipid levels above the optimum ranges defined by American Heart Association (AHA) that have an association with dietary habits. This is alarming and can impact the health of future healthcare workers. There is a need to investigate the factors and remedies to help medical students to follow a healthy diet and a healthy lifestyle.

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Obesity and Dyslipidemia: A Review of Current Evidence

Cited by 25 publications

References 146 publications

Role of newly designed anthropometric parameters in assessment of gonadotropic hormones and lipid fractions in females

Role of newly designed anthropometric parameters in assessment of gonadotropic hormones and lipid fractions in females

The assessment of leukocyte systemic inflammation index ratios in dyslipidemia patients with dry eye disease

From plate to profile: investigating the influence of dietary habits and inactive lifestyle on lipid profile in medical students at clerkship

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