Obesity and Dyslipidemia

Nussbaumerova, Barbora; Rosolova, Hana

doi:10.1007/s11883-023-01167-2

Cited by 25 publications

(6 citation statements)

References 51 publications

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“…Hyperlipidemia is a common complication of diet-induced obesity [ 38 ]. In this study, HFD-fed mice showed significantly higher serum TG ( Figure 3 f), TC ( Figure 3 g), LDL-C ( Figure 3 h), and HDL-C ( Figure 3 i) levels compared to those on an LFD, while dietary CPWE dramatically depressed these serum lipid levels in HFD-fed mice ( Figure 3 f–i).…”

Section: Resultsmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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Section: Resultsmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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“…GSEA provides additional support, revealing that the enrichment outcomes post-bariatric surgery are intricately linked with fatty acid and amino acid metabolism. Numerous obese individuals grapple with lipid metabolism disorders, notably abdominal obesity, elevating cardiometabolic risk due to atherogenic dyslipidemia [24]. Nutrient composition, particularly fatty acids, can signi cantly impact lipid levels.…”

Section: Discussionmentioning

confidence: 99%

Identification of the critical genes and signaling pathways in subcutaneous adipose tissue after bariatric surgery based on the GEO database

Han,

Wang,

Wang

et al. 2024

Preprint

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This study aimed to explore potential biomarkers and mechanisms following bariatric surgery. Two gene expression profiles from the Gene Expression Omnibus (GEO) were analysed to identify differentially expressed genes (DEGs) in subcutaneous adipose tissue (AT) post-bariatric surgery. Subsequently, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene-Set Enrichment Analysis (GSEA), and Protein-Protein Interaction (PPI) network analyses were employed to identify hub genes and associated pathways. Among the DEGs, 29 genes were downregulated. Enrichment analysis revealed that the downregulated DEGs significantly participated in inflammatory responses. GSEA provided comprehensive evidence that most genes were enriched in pro-inflammatory pathways before surgery, while after surgery, most genes were enriched in metabolism. In the PPI network, five key genes, including TREM2, MNDA, HP, C5AR1, and S100A8, were identified, with most validated as highly expressed in obesity by the Attie Lab Diabetes and another dataset, GSE72158. Bariatric surgery induces a significant shift from an obesity-promoting inflammatory state to an anti-inflammatory state, accompanied by improvements in adipocyte metabolic function. This represents a key mechanism for the enhancement of adipose tissue function following bariatric surgery. This study deepens the understanding of the benefits of bariatric surgery and provides potential biomarkers or therapeutic targets.

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“…Modifying the cholesterol balance has a substantial effect on the adipocyte metabolism of obese animals or humans [ 15 – 17 ]. EDCs, cholesterol metabolism and obesity are highly correlated [ 18 , 19 ]. Investigating the potential impact of environmental phenols on obesity metabolism via their influence on cholesterol levels could shed light on the role of cholesterol as a mediator between obesity and environmental phenols.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol mediates the effects of single and multiple environmental phenols in urine on obesity

Yu,

Zhang,

Yuan

et al. 2024

Lipids Health Dis

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Background Overweight and obesity are among the leading chronic diseases worldwide. Environmental phenols have been renowned as endocrine disruptors that contribute to weight changes; however, the effects of exposure to mixed phenols on obesity are not well established. Methods Using data from adults in National Health and Nutrition Examination Survey, this study examined the individual and combined effects of four phenols on obesity. A combination of traditional logistic regression and two mixed models (weighted quantile sum (WQS) regression and Bayesian kernel-machine regression (BKMR)) were used together to assess the role of phenols in the development of obesity. The potential mediation of cholesterol on these effects was analyzed through a parallel mediation model. Results The results demonstrated that solitary phenols except triclosan were inversely associated with obesity (P-value < 0.05). The WQS index was also negatively correlated with general obesity (β: 0.770, 95% CI: 0.644–0.919, P-value = 0.004) and abdominal obesity (β: 0.781, 95% CI: 0.658–0.928, P-value = 0.004). Consistently, the BKMR model demonstrated the significant joint negative effects of phenols on obesity. The parallel mediation analysis revealed that high-density lipoprotein mediated the effects of all four single phenols on obesity, whereas low-density lipoprotein only mediated the association between benzophenol-3 and obesity. Moreover, Cholesterol acts as a mediator of the association between mixed phenols and obesity. Exposure to single and mixed phenols significantly and negatively correlated with obesity. Cholesterol mediated the association of single and mixed environmental phenols with obesity. Conclusions Assessing the potential public health risks of mixed phenols helps to incorporate this information into practical health advice and guidance.

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Obesity and Dyslipidemia

Cited by 25 publications

References 51 publications

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Identification of the critical genes and signaling pathways in subcutaneous adipose tissue after bariatric surgery based on the GEO database

Cholesterol mediates the effects of single and multiple environmental phenols in urine on obesity

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