Obesity and diabetes: An update

Verma, Shalini; Hussain, M. Ejaz

doi:10.1016/j.dsx.2016.06.017

Cited by 240 publications

(182 citation statements)

References 118 publications

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“…DM2 is directly associated with obesity, which produces peripheral insulin resistance and leads to the medium- or long-term development of DM2 [3]. …”

Section: Introductionmentioning

confidence: 99%

Health and quality of life outcomes impairment of quality of life in type 2 diabetes mellitus: a cross-sectional study

Zurita‐Cruz

Manuel‐Apolinar

Arellano-Flores

et al. 2018

Health Qual Life Outcomes

104

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BackgroundType 2 diabetes mellitus (DM2) is a chronic disease, and for treatment to succeed, it is necessary to harmonize the mental health of the patient with the environment, which impacts quality of life and adherence to medical regimens. The objetive of this study is describe the quality of life of patients with DM2 and the factors relates to its modification.MethodsThis investigation was a cross-sectional study. Patients over 18 years of age with DM2 were selected. The following variables related to quality of life were studied: age, sex, occupation, marital status, years of DM2 evolution, comorbidities and presence of depression (Beck Depression Inventory). Perceived quality of life was measured with a health-related quality of life (HRQoL) scale, the 36-Item Short-Form Survey (SF-36). Patients were classified according to SF-36 HRQoL score (< 50, 51-75 and > 76 points).ResultsAmong the 1394 patients included, the median age was 62 years. Global HRQoL had a median of 50.1 points. Bivariate analysis showed that age, marital status, sex, occupation, comorbidities, duration of DM2 and comorbidities had impacts on HRQoL. The logistic regression model identified age (odds ratio [OR] 1.04) and depression (OR 4.4) as independent factors that influenced overall quality of life.ConclusionsPatients with DM2 have poor HRQoL, which is associated with a high frequency of depression. Older age and the presence of depression impair patient HRQoL.Trial registrationR-2013-781-052. Registered 20 December 2014.

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“…DM2 is directly associated with obesity, which produces peripheral insulin resistance and leads to the medium- or long-term development of DM2 [3]. …”

Section: Introductionmentioning

confidence: 99%

Health and quality of life outcomes impairment of quality of life in type 2 diabetes mellitus: a cross-sectional study

Zurita‐Cruz

Manuel‐Apolinar

Arellano-Flores

et al. 2018

Health Qual Life Outcomes

104

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“…Overweight and obesity is a pandemic that plays a major role in the pathogenesis of type 2 diabetes and a multitude of its complications [1-3]. The upsurge in obesity rates appears to be the primary factor for the recent increase in the prevalence of type 2 diabetes [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Impact of Obesity on the Metabolic Control of Type 2 Diabetes: Results of the Turkish Nationwide Survey of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Obesity Study)

et al. 2019

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Background: Obesity is the main obstacle for metabolic control in patients with type 2 diabetes. Turkey has the highest prevalence of obesity and type 2 diabetes in Europe. The effect of obesity on the metabolic control, and the macro- and microvascular complications of patients are not apparent. Objectives: This nationwide survey aimed to investigate the prevalence of overweight and obesity among patients with type 2 diabetes and to search for the impact of obesity on the metabolic control of these patients. We also investigated the independent associates of obesity in patients with type 2 diabetes. Methods: We consecutively enrolled patients who were under follow-up for at least 1 year in 69 tertiary healthcare units in 37 cities. The demographic, anthropometric, and clinical data including medications were recorded. Patients were excluded if they were pregnant, younger than 18 years, had decompensated liver disease, psychiatric disorders interfering with cognition or compliance, had bariatric surgery, or were undergoing renal replacement therapy. Results: Only 10% of patients with type 2 diabetes (n = 4,648) had normal body mass indexes (BMI), while the others were affected by overweight (31%) or obesity (59%). Women had a significantly higher prevalence of obesity (53.4 vs. 40%) and severe obesity (16.6 vs. 3.3%). Significant associations were present between high BMI levels and lower education levels, intake of insulin, antihypertensives and statins, poor metabolic control, or the presence of microvascular complications. Age, gender, level of education, smoking, and physical inactivity were the independent associates of obesity in patients with type 2 diabetes. Conclusion: The TEMD Obesity Study shows that obesity is a major determinant of the poor metabolic control in patients with type 2 diabetes. These results underline the importance of prevention and management of obesity to improve health care in patients with type 2 diabetes. Also, the results point out the independent sociodemographic and clinical associates of obesity, which should be the prior targets to overcome, in the national fight with obesity.

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“…Both of these metabolic disorders are characterized by defects of insulin action [6]. It has received wide agreement that the potential cause of IR in obesity are the decreased storage capacity of adipocytes and the elevated plasma free fatty acid levels, which further lead to the accumulation of ectopic fat and lipotoxicity in livers and muscles [5, 28].…”

Section: Discussionmentioning

confidence: 99%

“…Adiposity causes sustained increase in serum free fatty acid which results in the systemic insulin resistance (IR) [5]. Synergy of adiposity and IR may further increase the risk for type 2 diabetes mellitus (T2DM) [6]. …”

Section: Introductionmentioning

confidence: 99%

Relationships of Insulin Action to Age, Gender, Body Mass Index, and Waist Circumference Present Diversely in Different Glycemic Statuses among Chinese Population

Pang

Man

Song

et al. 2018

Journal of Diabetes Research

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Introduction To study the influence of different glycemic statuses on the relationship of insulin action to age, gender, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) among Chinese population. Methods A total of 35,327 participants (17,456 males and 17,871 females) were included in this nationally representative cross-sectional study. Glycemic status was defined according to the 2010 American Diabetes Association criteria. Fasting insulin was measured by the chemiluminescence method. Results Insulin and HOMA-IR levels were the highest in newly diagnosed diabetes and were lowest in normal fasting glucose (NFG) (P < 0.001). Insulin and HOMA-IR levels were higher in females (P < 0.001) than in males with previously diagnosed diabetes and impaired fasting glucose (IFG) and NFG, meanwhile decreased with age (P < 0.001) among IFG and NFG participants. As compared with participants with a BMI from 18.5 to 19.9, those in the lowest BMI category (<18.5) had a significantly elevated risk of IR (OR, 1.96; 95% CI, 1.01–3.80), as did those in the higher BMI categories among NFG participants. The risk of IR increased with WC and WHtR, and the response was linear (P < 0.001 for linear trend) for the participants with NFG but not in those with IFG. Conclusions Different glycemic statuses significantly affect the relationships of insulin action to age, gender, BMI, WC, and WHtR among Chinese population.

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Obesity and diabetes: An update

Cited by 240 publications

References 118 publications

Health and quality of life outcomes impairment of quality of life in type 2 diabetes mellitus: a cross-sectional study

Health and quality of life outcomes impairment of quality of life in type 2 diabetes mellitus: a cross-sectional study

Impact of Obesity on the Metabolic Control of Type 2 Diabetes: Results of the Turkish Nationwide Survey of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Obesity Study)

Relationships of Insulin Action to Age, Gender, Body Mass Index, and Waist Circumference Present Diversely in Different Glycemic Statuses among Chinese Population

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