Obesity and complicated diverticular disease of the colon

Rodríguez-Wong, Ulises; Cruz-Rubín, Carlos; Pinto-Angulo, Víctor Manuel; Alvarez, Javier García

doi:10.1016/j.circen.2015.09.013

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…In addition, to the higher risk of occurrence of diverticulosis in obese patients, it has been demonstrated the obesity might also be associated with a higher risk of complication. Indeed, an association has been demonstrated between an increased incidence and severity of complicated diverticular disease [54]. In particular data coming from a population study have shown that among several factors such as hypertension, dyslipidemia, and chronic kidney disease, increasing BMI and increasing visceral adipose tissue were associated with diverticular bleeding [55].…”

Section: Diverticulosismentioning

confidence: 99%

Role of Overweight and Obesity in Gastrointestinal Disease

et al. 2019

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The prevalence of obesity is increasing worldwide, leading to a severe impairment of overall health. Actually, obesity has been associated with several pathological conditions, causing an excess overall mortality. In particular, overweight and obesity are well known risk factors for a variety of gastrointestinal (GI) disorders i.e., functional GI disorders as well as, inflammatory bowel disease (IBD), pancreatitis, and GI cancer. The aim of the present review is to summarize the potential role of overweight and obesity in GI disease with particular focus on plausible biological mechanisms that could explain the association between obesity and GI disease based on the most recent evidence in the literature.

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Section: Diverticulosismentioning

confidence: 99%

Role of Overweight and Obesity in Gastrointestinal Disease

et al. 2019

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“…However, in this study diabetes mellitus has no significant association with septic complications of diverticular disease. It is interesting to note that a study reported that obesity (a risk factor for diabetes mellitus) is associated with an increased incidence and severity of complicated diverticular disease, which is diverticulitis (27). Our study is limited also by the absence of a sub-analysis of the severity of the comorbidity; hypertension and diabetes mellitus.…”

Section: Discussionmentioning

confidence: 85%

Proportion of Colonic Diverticulosis and Its Associated Factors among Patients Underwent Colonoscopy

Nik Mazlan,

Mohamed Sidek,

Zakaria

et al. 2024

Düzce Tıp Fakültesi Dergisi

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Aim: Diverticular disease is one of the most common gastrointestinal disorders to date, with a notable rising trend in developing countries. However, the proportion of colonic diverticulosis and its associated factors among patients who have undergone colonoscopy remains controversial. This study aimed to determine the local data on the proportion of diverticular disease in the community, its complications, the association of diverticulosis with diabetes mellitus and hypertension, as well as demographic characteristics. Material and Methods: A retrospective review of medical records was performed among patients who had undergone colonoscopy between January and December 2019. Demographic and clinical characteristics, the presence of diabetes mellitus, hypertension, and diverticular disease and its complications were examined, and the association of diverticular disease and its complications with demographic and clinical characteristics were analyzed. Results: Out of 221 patients, 12.7% (n=28) of them had diverticular diseases with a slightly predominant right-sided occurrence (42.9%, n=12). There were significant associations with age (p=0.002), ethnicity (p=0.011), and hypertension (p=0.036), but not with gender and diabetes mellitus (p=0.261, and p=0.334, respectively). There was no significant association between hypertension and recurrence of complicated diverticulitis (p=0.741), septic complications (p=0.678), and diverticular bleeding (p=0.243). Diabetes mellitus was significantly associated with diverticular bleeding complications (p=0.001) but not with septic complications (p=0.418) and recurrence of complicated diverticulitis (p=0.629). Conclusion: This study showed almost a similar percentage of diverticulosis compared to previous local studies. Age, ethnicity, and hypertension were associated with the presence of diverticulosis, and diabetes mellitus was associated with diverticular bleeding.

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The Impact of Obesity on Mortality and Clinical Outcomes in Patients with Acute Diverticulitis in the United States

Makar

Pisano

Xia

et al. 2021

JGLD

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Background and Aims: Diverticular disease represents a leading cause of gastrointestinal-related hospitalizations. We sought to identify the adverse consequences of obesity on acute diverticulitis (AD) hospital admissions. By age 85, approximately two-thirds of individuals will develop diverticular disease and up to 25% will develop AD. Generally, obesity confers an increased risk of morbidity and mortality; however, its impact on hospitalized patients with AD are lacking. Methods: Utilizing ICD-9-CM codes from the National Inpatient Sample (January 2012 – October 2015) we identified patients with a primary discharge diagnosis of AD including 660,820 hospitalizations and 115,785 with obesity. Primary outcomes were mortality, length of stay, and hospitalization cost. Secondary outcomes were AD complications and the need for surgical interventions. Results: On multivariate analysis, obesity was not associated with an increased risk of mortality (OR=1.1, 95%CI: 0.87-1.41; p= 0.43). However, morbid obesity (BMI > 40 kg/m2) showed a significant increased risk of mortality (OR=1.69, 95%CI: 1.23-2.31; p<0.001). Obesity was associated with prolonged hospitalizations length of stay by 0.61 days (0.55-0.68; p <10-6), higher hospital charges $6,320 ($ 5,500-7,140; p<10-6), increased complicated diverticulitis 1.05 (1.01-1.1; p < 0.010) and required more surgical interventions for diverticulitis (OR=1.19, 95%CI: 1.15-1.23; p<10-6). Conclusion: Morbid obesity increases risk for mortality while obesity leads to longer hospitalization stays and greater healthcare cost as well as adverse clinical outcomes and more surgical interventions. Further interventions are required to address obesity and weight loss for patients with diverticulitis to improve clinical outcomes.

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Obesity and complicated diverticular disease of the colon

Cited by 4 publications

References 11 publications

Role of Overweight and Obesity in Gastrointestinal Disease

Role of Overweight and Obesity in Gastrointestinal Disease

Proportion of Colonic Diverticulosis and Its Associated Factors among Patients Underwent Colonoscopy

The Impact of Obesity on Mortality and Clinical Outcomes in Patients with Acute Diverticulitis in the United States

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