Obesity and asthma: A focused review

Tooba, Rubabin; Wu, Tianshi David

doi:10.1016/j.rmed.2022.107012

Cited by 8 publications

(6 citation statements)

References 121 publications

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“…Em pacientes asmáticos, a resistência à insulina (RI) tem sido associada ao risco elevado de exacerbações, a redução da função pulmonar a longo prazo e a resposta atenuada a esteroides sistêmicos e beta-adrenérgicos (TOOBA & WU, 2022). Portanto, a relação entre obesidade e a presença de asma é reforçada essencialmente pela presença da resistência insulínica, diferente de outras condições dentro da síndrome metabólica (SM).…”

Section: Capítulo IIunclassified

O Impacto Da Síndrome Do Ovário Policístico No Risco Cardiovascular

Santos¹,

Santos²,

Nunes³

et al. 2023

Atualizações Em Medicina: Associações Entre Condições E Novas Perspectivas

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Atualizações em medicina: associações entre condições e novas perspectivas está licenciado sob CC BY 4.0.Esta licença exige que as reutilizações deem crédito aos criadores. Ele permite que os reutilizadores distribuam, remixem, adaptem e construam o material em qualquer meio ou formato, mesmo para fins comerciais. O conteúdo da obra e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, não representando a posição oficial da Editora Amplla. É permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores. Todos os direitos para esta edição foram cedidos à Editora Amplla.

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Section: Capítulo IIunclassified

O Impacto Da Síndrome Do Ovário Policístico No Risco Cardiovascular

Santos¹,

Santos²,

Nunes³

et al. 2023

Atualizações Em Medicina: Associações Entre Condições E Novas Perspectivas

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“…A clinical research showed that obesity increased asthma severity 7 . Accumlating evidence has suggested that increased body mass index was linked to allergic and nonallergic asthma 8 . There was disagreement about the regulatory mechanism of obesity‐related asthma.…”

Section: Introductionmentioning

confidence: 99%

“… 7 Accumlating evidence has suggested that increased body mass index was linked to allergic and nonallergic asthma. 8 There was disagreement about the regulatory mechanism of obesity‐related asthma. In obesity, adipose tissues produce proinflammatory cytokines such as interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α), and thus obesity is regarded as a chronic systemic inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Plumbagin alleviates obesity‐related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway

Zhang,

Liang,

Liu

et al. 2023

Immunity Inflam & Disease

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BackgroundObesity‐related asthma, a specific type of asthma, tends to have more severe symptoms and more frequent exacerbations, and it is insensitive to standard medications. Plumbagin (PLB) has many positive effects on human health. However, it remains unclear whether PLB protects against obesity‐related asthma. The study investigated the effect of PLB on obesity‐related asthma.MethodsFour‐week‐old male C57BL6/J mice were fed either standard‐chow diet or high‐fat diet (HFD). The mice were sensitized to 100 μg ovalbumin (OVA) once a week and intraperitoneally injected with 1 mg/kg PLB once daily from Week 10 to 11 and then challenged with 10 μg OVA twice a day on Week 12. The lung tissue and bronchoalveolar lavage fluid (BALF) were collected 48 h after the first OVA challenge.ResultsHFD enhanced inflammatory cell infiltration within the airways and increased total inflammatory cell and eosinophil counts, levels of eosinophil‐related inflammatory cytokines, including interleukin‐4 (IL‐4), IL‐5, and eotaxin in BALF, and oxidative stress in the lung tissues of asthmatic mice. PLB reduced inflammatory cell infiltration in the airway walls, levels of eosinophil‐related inflammatory cytokines in BALF, and oxidative stress in lung tissues of obese asthmatic mice. In addition, PLB restored HFD‐induced decreases in adenosine monophosphate‐activated protein kinase (AMPK) phosphorylation.ConclusionThe study suggested that HFD exacerbated inflammation and oxidative stress, while PLB probably alleviated inflammation and oxidative stress and activated AMPK pathway to attenuate obesity‐associated asthma. Thus, PLB likely had the potential to treat obesity‐related asthma.

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“…Firstly, asthma inception, development and severity are influenced by an interacting host of genetic factors (Berube & Bosse, 2014 ) and inhaled offending triggers that vary in concentration and constitutional composition over time (Sheehan et al., 2017 ; Szram & Cullinan, 2012 ). The impact of these interactions also depends on the timing (e.g., age, menstrual cycle, pregnancy) and sequence of exposure throughout life (Tang et al., 2021 ), in addition to the diet (Williams et al., 2022 ), the lung and gut microbiota (Barcik et al., 2020 ; Tang et al., 2021 ), the presence of obesity (Tooba & Wu, 2022 ) and other co‐morbidities (Cazzola et al., 2022 ; Teodorescu et al., 2015 ), the current and historical intake of medications (Tan et al., 2021 ), the air temperature (Zhou et al., 2022 ), and levels of anxiety (Ye et al., 2021 ), physical activity (Kuder et al., 2021 ), sunshine (Alfredsson et al., 2020 ) and ambient oxygen (altitude) (de Nijs et al., 2020 ; Vinnikov et al., 2016 ). Secondly, investigations of humans in vivo rely on non‐invasive methods that lack precision (Bates & Irvin, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?

Gill

Rojas‐Ruiz

Boucher

et al. 2023

Experimental Physiology

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Mouse models are helpful in unveiling the mechanisms underlying sex disparities in asthma. In comparison to their female counterparts, male mice are hyperresponsive to inhaled methacholine, a cardinal feature of asthma that contributes to its symptoms. The physiological details and the structural underpinnings of this hyperresponsiveness in males are currently unknown. Herein, BALB/c mice were exposed intranasally to either saline or house dust mite once daily for 10 consecutive days to induce experimental asthma. Twenty-four hours after the last exposure, respiratory mechanics were measured at baseline and after a single dose of inhaled methacholine that was adjusted to trigger the same degree of bronchoconstriction in both sexes (it was twice as high in females). Bronchoalveolar lavages were then collected, and the lungs were processed for histology. House dust mite increased the number of inflammatory cells in bronchoalveolar lavages to the same extent in both sexes (asthma, P = 0.0005; sex, P = 0.96). The methacholine response was also markedly increased by asthma in both sexes (e.g., P = 0.0002 for asthma on the methacholine-induced bronchoconstriction). However, for a well-matched bronchoconstriction between sexes, the increase in hysteresivity, an indicator of airway narrowing heterogeneity, was attenuated in males for both control and asthmatic mice (sex, P = 0.002). The content of airway smooth muscle was not affected by asthma but was greater in males (asthma, P = 0.31; sex, P < 0.0001). These results provide further insights regarding an important sex disparity in mouse models of asthma. The increased amount of airway smooth muscle in males might contribute functionally to their greater methacholine response and, possibly, to their decreased propensity for airway narrowing heterogeneity.

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Obesity and asthma: A focused review

Cited by 8 publications

References 121 publications

O Impacto Da Síndrome Do Ovário Policístico No Risco Cardiovascular

O Impacto Da Síndrome Do Ovário Policístico No Risco Cardiovascular

Plumbagin alleviates obesity‐related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway

More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?

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