Obesity and Angiolymphatic Invasion in Primary Breast Cancer

Gillespie, Erin F.; Sorbero, Melony E.; Hanauer, David A.; Sabel, Michael S.; Herrmann, Emily; Weiser, Laura J.; Jagielski, Christina H.; Griggs, Jennifer J.

doi:10.1245/s10434-009-0797-6

Cited by 39 publications

(33 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was concluded that menopausal status may be a factor mitigating the effect of obesity on the incidence of TNBC. A South American study drew similar conclusions, but this may be attributed to the higher incidence rates of TNBC observed among younger women of African American descent (15 (17). From this research, the high rates of TNBC have been primarily attributed to diabetes.…”

Section: Tnbc Patients Tend To Have Larger Tumors Higher T Stage Andmentioning

confidence: 56%

Triple‑negative breast cancer and its?association with obesity (Review)

Zou

Chen

et al. 2017

mol clin onc

View full text Add to dashboard Cite

Abstract. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of the estrogen and progesterone receptor and does not overexpress human epidermal growth factor 2 receptor protein. TNBC is associated with special characteristics, including aggressiveness, poor prognosis and poor response to treatment, and has been attracting increasing attention worldwide. Obesity is a well-documented factor exerting a significant effect on the development of breast cancer, including TNBC. The purpose of the present review was to focus on the association between obesity and TNBC and provide a summary of novel research findings. The aim was to highlight the association between TNBC and obesity and provide an overview of novel outlooks on clinical issues, biological rationale, novel targeted therapies and prognosis, in order to draw attention to the significance of weight management, primary prevention, early diagnosis and treatment of this intractable disease.

show abstract

Section: Tnbc Patients Tend To Have Larger Tumors Higher T Stage Andmentioning

confidence: 56%

Triple‑negative breast cancer and its?association with obesity (Review)

Zou

Chen

et al. 2017

mol clin onc

View full text Add to dashboard Cite

show abstract

“…IL-6 has mitotic and anti-apoptotic effect and higher levels of IL-6 is associated with poorer survival (Bachelot et al, 2003). However, previous studies did not concluded in same results regarding the idea that obese women's tumor has more aggressive phenotype; obesity did not show association with triple negative breast cancer (Maiti et al, 2010), in contrary it was correlated with larger tumor size (Ove Maehle et al, 2001) and more lymphovascular invasion (Gillespie et al, 2010).…”

Section: Discussionmentioning

confidence: 96%

Effects of Obesity on Presentation of Breast Cancer, Lymph Node Metastasis and Patient Survival: A Retrospective Review

Kaviani

Neishaboury²,

Mohammadzadeh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: As data on the relation between obesity and lymph node ratio are missing in the literature, we here aimed to assess the impact of obesity on this parameter and other clinicopathological features of breast cancer cases and patient survival. Materials and Methods: Medical data of 646 patients, all referred to two centers in Tehran, Iran, were reviewed. Factors that showed significant association on univariate analysis were entered in a regression model. Kaplan-Meier and Cox-regression were employed for survival analysis. Results: Obesity was correlated with the expression of estrogen and progesterone receptor (p=0.004 and p=0.039, respectively), metastasis to axillary lymph nodes (p=0.017), higher lymph node rate (p<0.001) and larger tumor size (p<0.001). The effect of obesity was stronger in premenopausal women. There was no association between obesity and expression of human epidermal growth factor receptor. Three factors showed independent association with BMI on multivariate analysis; tumor size, estrogen receptor and lymph node ratio. Obesity was predictive of shorter disease-free survival with a hazard ratio of 3.324 (95%CI: 1.225-9.017) after controlling for the above-mentioned variables. Conclusions: The findings of this study support the idea that obese women experience more advanced disease with higher axillary lymph node ratio, and therefore higher stage at the time of diagnosis. Furthermore, obesity was associated with poorer survival independent of lymph node rate.

show abstract

“…The issue is one with important therapeutic implications. Gillespie et al (2010) found that diabetes was associated with an increased risk for 'triple-negative' breast cancer, a tumor type that is negative for ER, PR, and HER2, possesses an aggressive metastatic phenotype, and has a poor prognosis. While this single report requires verification, the metabolic syndrome, with independent association for the blood glucose, has been associated with triple-negative breast cancer (Maiti et al 2010).…”

Section: Commentarymentioning

confidence: 99%

The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression

Rose

Vona-Davis

2012

Endocrine-Related Cancer

138

125

View full text Add to dashboard Cite

Epidemiological studies have related hyperinsulinemia and type 2 diabetes to an increased breast cancer risk, an aggressive and metastatic phenotype, and a poor prognosis. Furthermore, diabetic retinopathy arises from pathological angiogenesis, which is also essential for breast cancer growth and metastasis. Insulin stimulates the proliferation of some human breast cancer cell lines in vitro by mechanisms that use both the phosphatidylinositol-3 kinase and the mitogen-activated protein kinase/Akt signaling pathways; it is also a cell survival (anti-apoptotic) agent and enhances tumor cell migration and invasive capacity. Hyperinsulinemia affects breast cancer cells via the endocrine system, but experimental studies suggest the importance of paracrine mechanisms operating by the effects of insulin on the secretion of adipokines from tumor-associated adipose tissue. In such a system, one adipokine, leptin, has stimulatory paracrine effects on breast cancer cell proliferation and survival, while a second, adiponectin, is inhibitory. Leptin, vascular endothelial growth factor, another insulin-regulated adipokine, and insulin itself also stimulate angiogenesis. Insulin has complex interactions with estrogens: it induces adipose stromal cell aromatase and tumor cell sex steroid hormone receptor expression and suppresses sex hormonebinding globulin, which may enhance estrogen synthesis and bioactivity with consequent promotion of estrogen-dependent breast cancer. All these actions influence the later steps in breast cancer development but genetic studies are also revealing connections between gene abnormalities related to type 2 diabetes and the initiation stage of breast carcinogenesis. Understanding the various mechanisms by which insulin participates in breast cancer cell biology provides opportunities for novel approaches to treatment.

show abstract

Obesity and Angiolymphatic Invasion in Primary Breast Cancer

Cited by 39 publications

References 50 publications

Triple‑negative breast cancer and its?association with obesity (Review)

Triple‑negative breast cancer and its?association with obesity (Review)

Effects of Obesity on Presentation of Breast Cancer, Lymph Node Metastasis and Patient Survival: A Retrospective Review

The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression

Contact Info

Product

Resources

About