Obesity and Age at Diagnosis of Endometrial Cancer

Nevadunsky, Nicole S.; Arsdale, Anne Van; Strickler, Howard D.; Moadel, Alyson B.; Kaur, Gurpreet; Levitt, Joshua; Girda, Eugenia; Goldfinger, Mendel; Goldberg, Gary L.; Einstein, Mark H.

doi:10.1097/aog.0000000000000381

Cited by 92 publications

(75 citation statements)

References 15 publications

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“…Our analysis demonstrates that nonendometrioid endometrial cancer rates have shown the greatest incidence rate increases over the last decade, supporting Wartko and colleagues in their conclusion that obesity is contributing to, but not solely responsible for, the rising incidence rates of endometrial cancer (2). In addition, it is possible that obesity is associated with an earlier age of onset, particularly for endometrioid cancers (40). Continued surveillance of this issue, also considering morbidity and mortality, is warranted.…”

Section: Discussionsupporting

confidence: 76%

The Growing Burden of Endometrial Cancer: A Major Racial Disparity Affecting Black Women

Coté

Ruterbusch

Olson

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

198

148

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Background: In contrast with the decreasing incidence seen for most cancers, endometrial cancer has been increasing in the United States. We examined whether the increasing incidence and mortality from endometrial cancer are equally distributed by race/ethnicity and tumor histologic subtype.Methods: Surveillance, Epidemiology, and End Results (SEER) endometrial cancer incidence and mortality data were obtained from 2000 to 2011. Age-adjusted incidence and incidence-based mortality rates, 95% confidence intervals, and annual percent changes (APC) were calculated. Rate ratios were calculated to compare racial/ethnic groups. Five-year relative survival rates were presented to explore survival by stage at diagnosis.Results: Incidence rates for endometrial cancers are rising across all racial/ethnic groups, with the greatest APC seen among non-Hispanic black (NHB) and Asian women (APC, 2.5 for both).

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Section: Discussionsupporting

confidence: 76%

The Growing Burden of Endometrial Cancer: A Major Racial Disparity Affecting Black Women

Coté

Ruterbusch

Olson

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

198

148

View full text Add to dashboard Cite

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“…3 In addition, increasing rates of obesity appears to be contributing to higher rates of endometrial cancer in the younger age population as well. 5 Many patients who have undergone hysterectomy for endometrial or early-stage cervical cancer require postoperative pelvic radiotherapy with a number of randomized trials showing improvements in local control and progression free survival. 6 To reduce surrounding normal tissue dosing and overall short-term and long-term side effects from treatment, radiation oncologists have transitioned away from conventional external beam plans with large treatment fields and have trended to more conformal plans.…”

Section: Introductionmentioning

confidence: 99%

Should We Customize PTV Expansions for BMI?: Daily Cone Beam Computerized Tomography to Assess Organ Motion in Postoperative Endometrial and Cervical Cancer Patients

Amini¹,

Vinogradskiy²,

Rusthoven³

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

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“…Accordingly, Reeves et al predicted that up to 51 % of endometrial cancer cases could be attributable to obesity (Reeves et al 2007). Nevadunsky et al report a strong correlation between obesity and younger age at diagnosis, and Duska et al found that women aged 24-40 years and BMI >30 were associated with stage I, grade I disease (Duska et al 2001;Nevadunsky et al 2014). In general, obesity induces a hyperestrogenic state due to the conversion of adrostenedione to estrone in peripheral adipose tissue.…”

Section: Obesity and Endometrial Cancermentioning

confidence: 93%