Obesity, adipose tissue function and the role of vitamin D

Koszowska, Aneta; Nowak, Justyna; Dittfeld, Anna; Brończyk-Puzoń, Anna; Kulpok, Agata; Zubelewicz-Szkodzińska, Barbara

doi:10.5114/ceji.2014.43732

Cited by 37 publications

(28 citation statements)

References 19 publications

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“…VDRs and the 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1) genes are all expressed in human adipocytes [139]. Vitamin D levels are inversely related to obesity including body fat percentage (BFP), body mass index (BMI), and waist circumference [140,141]. Vitamin D supplementation for 16 weeks reduces visceral fat in overweight and obese adults [142].…”

Section: Effects Of Vitamin D On the Adipose Tissuementioning

confidence: 99%

Vitamin D and Physical Activity

Koundourakis¹,

Margioris²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is synthesized in the skin following exposure to ultraviolet radiation, producing cholecalciferol, while only a small percentage of the circulating vitamin D is of exogenous origin deriving from food. Following two sequential hydroxylations, in the liver and in the kidneys, vitamin D is fully activated. Although its role in bone physiology and calcium homeostasis is well documented, there is emerging evidence that vitamin D exerts a plethora of additional effects on most tissues regulating the musculoskeletal, cardiovascular, and immune systems as well as energy homeostasis. Its deficiency/insufficiency poses a major public health problem observed in all age groups and regardless of latitude and insolation. In muscles, vitamin D deficiency is associated with a decline in neuromuscular function including muscular strength, walking speed, balance, jumping and sprinting performance, and aerobic capacity, although the evidence is still weak regarding its effects in the young and the athletes. Supplementation counteracts the negative effects of vitamin D deficiency on performance although in individuals with adequate levels of vitamin D, additional supplementation does not appear to enhance further physical capabilities. The aim of this chapter is to review our current understanding of diverse effects of vitamin D in physical performance in athletic and nonathletic populations.

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Section: Effects Of Vitamin D On the Adipose Tissuementioning

confidence: 99%

Vitamin D and Physical Activity

Koundourakis¹,

Margioris²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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“…In children with growth hormone deficiency (GHD), ALP and BALP levels are decreased and rise significantly after the initiation of recombinant human growth hormone (rhGH) treatment (Juul et al, 1994;Ono et al, 1996;Tobiume et al, 1997;Eapen et al, 2008;Korpal-Szczyrska et al, 2008;Witkowska-Sędek et al, 2014). Vitamin D, which is necessary for normal calcium-phosphorus homeostasis and skeleton mineralization, also influences bone turnover during growth, but its role has not been fully explained (Barnes et al, 2006;Paradowska et al, 2007;Anderson et al, 2013;Koszowska et al, 2014;Thiering et al, 2015;Larijani et al, 2016;Ciresi et al, 2017;Schwetz et al, 2017). The effects of the GH/IGF-1 axis on bone turnover can be evaluated using the measurement of bone turnover markers (BTMs), including ALP and BALP (Ono et al, 1996;Locatelli et al, 2014;Devesa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The relationships of alkaline phosphatase and bone alkaline phosphatase to the growth hormone/insulin-like growth factor-1 axis and vitamin D status in children with growth hormone deficiency

et al. 2018

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The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. The GH/IGF-1 axis and vitamin D can mutually modulate each other's metabolism and influence the activation of cell proliferation, maturation, and mineralization as well as bone resorption. The aim of this study was to evaluate the reciprocal associations between bone formation markers [alkaline phosphatase (ALP), bone alkaline phosphatase (BALP)], the GH/IGF-1 axis and 25-hydroxyvitamin D [25(OH)D] in children with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) therapy. ALP, BALP, 25(OH)D and IGF-1 levels were evaluated in 53 patients included in this prospective three-year study. ALP, BALP and IGF-1 increased during rhGH therapy. Baseline ALP activity correlated positively with baseline height velocity (HV). ALP and BALP activity at 12 months correlated positively with HV in the first year of therapy. We found positive correlations between ALP and IGF-1 at baseline and during the first year of therapy, between BALP activity at 12 months and rhGH dose in the first year of therapy, and between doses of cholecalciferol in the first year of rhGH therapy and early changes in BALP activity during rhGH therapy. Our results indicate that vitamin D supplementation enhances the effect of rhGH on bone formation process, which could improve the effects of rhGH therapy. ALP and BALP activity are useful in the early prediction of the effects of rhGH therapy, but their utility as long-term predictors seemed insufficient.

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“…Cholesterol is required for the cancer cell growth and survival for being a basic component of cell membranes and an obligate precursor molecule of various steroid hormones, bile acids [ 123 ], and vitamin D [ 124 ]. Its dietary absorption, synthesis, release, transportation, and storage are all tightly regulated [ 125 ].…”

Section: Cholesterol Metabolismmentioning

confidence: 99%

Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming

Yang

Sun

et al. 2016

Advances in Experimental Medicine and Biology

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Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the "dark matter in life," functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.

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Obesity, adipose tissue function and the role of vitamin D

Cited by 37 publications

References 19 publications

Vitamin D and Physical Activity

Vitamin D and Physical Activity

The relationships of alkaline phosphatase and bone alkaline phosphatase to the growth hormone/insulin-like growth factor-1 axis and vitamin D status in children with growth hormone deficiency

Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming

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