Obesity, a major risk factor for immunity and severe outcomes of COVID-19

Amin, Mohammad Tohidul; Fatema, Kaniz; Hussain, Fahad; Bhowmik, Dipty Rani; Hossain, Mohammad Salim

doi:10.1042/bsr20210979

Cited by 14 publications

(15 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study is further closely located to a previous report that indicated increased risks of acquiring COVID-19 infection among pediatrics with medical comorbidities and certain disorders such as obesity [57]. Obesity should be recruited as individual risk factors for higher COVID-19 severity and mortality outcomes [58]. Obesity is a well-known risk factor for acquiring COVID-19 and infections in general [59].…”

Section: Discussionsupporting

confidence: 70%

Biochemical and Anthropometric Nutritional Assessment in Children Infected with COVID-19: A Cross-sectional Study

Ibrahim

Helmy

Amin

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

Background: Severe acute respiratory syndrome has led to a pandemic of coronavirus disease 2019 (COVID-19). Malnutrition either biochemically or anthropometrically is a well-known risk factor for COVID-19 and may be the vice versa Objectives : To investigate the prevalence of malnutrition in children infected with COVID-19 through evaluating the nutritional biomarkers such as serum electrolytes, serum albumin and hemoglobin together with the anthropometric assessment. Methods: A cross sectional study that was conducted at ElMatria Teaching Hospital for all children admitted with confirmed COVID-19 over a period of 6 months from 1st February 2021 to the end of July, 2021. Nutritional biochemical evaluation included serum electrolytes particularly the potassium and other nutritional biomarkers such as serum albumin and hemoglobin. Nutritional anthropometric evaluation depended on BMI (body mass index), the height/length, weight for length and weight for height..The prevalence of malnutrition esp. hypokalemia was the main outcome. Results: Hypokalemia was present in 21.8% of the study participants . Other nutritional biomarkers were found as hyponatremia, hypocalcemia , hypophosphatemia, hypomagnesemia were detected in 49.1% , 38.2%,21.8% and 34.5% of the study subjects respectively. Anthropometric malnutrition was present in most of the enrolled children with COVID-19 in the study (65.5 % (n= 36) )through which overweight and obese children occupied a greater percentage. Conclusion: Malnutrition either biochemically or anthropometrically could be linked to COVID-19 in children. COVID-19 could have negative outcomes on the nutritional status such as electrolytes disturbances. Both malnutrition and COVID-19 are considered synergistic associations Keywords: Malnutrition. COVID-19. Children. Hypokalemia. Obesity

show abstract

Section: Discussionsupporting

confidence: 70%

Biochemical and Anthropometric Nutritional Assessment in Children Infected with COVID-19: A Cross-sectional Study

Ibrahim

Helmy

Amin

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…Our findings are consistent with those of previous research on the effect of obesity on immunological fitness, which demonstrated a correlation between weight and ISQ scores. Obesity is a distinct risk factor [ 33 ]. Obesity has recently been associated with higher mortality and disease severity during the COVID-19 pandemic [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Interplay Between Sociodemographic Variables, Physical Activity, Sleep, Dietary Habits, and Immune Health Status: A Cross-Sectional Study From Saudi Arabia's Western Province

Alharbi¹,

Altwaim²,

Alharbi³

et al. 2023

Cureus

View full text Add to dashboard Cite

Background: In addition to developing effective therapeutic approaches, the maintenance of health also constitutes lifestyle and behavioral aspects related to being more resilient in the event of future illness. Reduced immune health has been linked to reports of more frequent and severe infections as well as a variety of non-communicable diseases, both of which may eventually place a significant burden on the healthcare system. Several lifestyles and behaviors can influence immune health, both positively and negatively. Accordingly, this study aimed to evaluate the immune health status and investigate its relationship with widely practiced lifestyle behaviors that are thought to affect immunological functioning.Design and method: Saudi Arabian citizens and international residents of the Western Province were invited to participate in this cross-sectional web-based survey through an online advertisement. The integrated questionnaire on lifestyle (Arab Teens Lifestyle Study) and immune health status (Immune Status Questionnaire (ISQ)) was completed in November 2022 by 1230 participants. Descriptive analysis, Mann-Whitney U test, chi-square, or Fisher's exact test was utilized to investigate the relationships between study variables and immune health status groups. Spearman's or Pearson's correlation coefficients were used to determine correlations between the overall ISQ scores and study variables.Results: Of the 925 study participants, 34.7% scored below 6 on the ISQ. Of the respondents, 50% had a body mass index of 25 or higher, and 46.3% reported sleeping less than four hours each night. Of the participants, 62-82% did not engage in any form of physical activity. The associations between the ISQ score and weight (p = 0.006), total sleep time per night (p = 0.001), duration of household activities (p < 0.001), and smoking status (p = 0.001) were statistically significant.Conclusions: According to the data presented here, reduced immune health as measured by ISQ < 6 was prevalent among residents of Saudi Arabia's Western Province and correlated significantly with obesity, sleep duration, and smoking status. Various measures to mitigate the negative impact of an unhealthy lifestyle on public health and to reverse the observed poor immune health and their economic consequences are highly required.

show abstract

“…[18] According to research statistics, the prevalence rate of obesity and abdominal obesity in China is 13.2% and 44%, respectively, indicating that the number of patients should not be underestimated. [19] Obesity is an independent risk factor for the onset of influenza. Generally, obese people with a BMI of 30-35 kg/m 2 and more than 35 kg/m 2 have 1.45 and 2.12 times, respectively, the risk of being hospitalizationed for influenza.…”

Section: Obesity and Morbidity Of Covid-19mentioning

confidence: 99%

Section: Obesity and Morbidity Of Covid-19mentioning

confidence: 99%

Obesity and coronavirus disease 2019

Fei

Feng

Luo

et al. 2022

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) pandemic has brought severe challenges to global public health. Many studies have shown that obesity plays a vital role in the occurrence and development of COVID-19. Obesity exacerbates COVID-19, leading to increased intensive care unit hospitalization rate, high demand for invasive mechanical ventilation, and high mortality. The mechanisms of interaction between obesity and COVID-19 involve inflammation, immune response, changes in pulmonary dynamics, disruptions of receptor ligands, and dysfunction of endothelial cells. Therefore, for obese patients with COVID-19, the degree of obesity and related comorbidities should be evaluated. Treatment methods such as administration of anticoagulants and anti-inflammatory drugs like glucocorticoids and airway management should be actively initiated. We should also pay attention to long-term prognosis and vaccine immunity and actively address the physical and psychological problems caused by longterm staying-at-home during the pandemic. The present study summarized the research to investigate the role of obesity in the incidence and progression of COVID-19 and the psychosocial impact and treatment options for obese patients with COVID-19, to guide the understanding and management of the disease.

show abstract

Obesity, a major risk factor for immunity and severe outcomes of COVID-19

Cited by 14 publications

References 167 publications

Biochemical and Anthropometric Nutritional Assessment in Children Infected with COVID-19: A Cross-sectional Study

Biochemical and Anthropometric Nutritional Assessment in Children Infected with COVID-19: A Cross-sectional Study

Interplay Between Sociodemographic Variables, Physical Activity, Sleep, Dietary Habits, and Immune Health Status: A Cross-Sectional Study From Saudi Arabia's Western Province

Obesity and coronavirus disease 2019

Contact Info

Product

Resources

About