Oat β-glucan alleviates DSS-induced colitis<i>via</i>regulating gut microbiota metabolism in mice

Bai, Junying; Zhao, Jiajia; Al‐Ansi, Waleed; Wang, Jing; Li, Xue; Liu, Jinxin; Wang, Yu; Fan, Mingcong; Qian, Haifeng; Li, Yan

doi:10.1039/d1fo01446c

Cited by 42 publications

(40 citation statements)

References 57 publications

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“…In addition, increased consumption of coarse cereals containing dietary fiber contributes to healthy functioning of the intestine. Oat β-glucan mitigated the inflammatory status in colon, enhanced colonic barrier function, and increased gut microbiota-derived SCFAs (butyrate) in vivo [46,47]. Tartary buckwheat-resistant starch improved intestinal health by regulating the gut microbiota composition and increasing the yield of SCFAs in HFD fed mice [48].…”

Section: Discussionmentioning

confidence: 98%

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Wang

Guo

et al. 2022

Nutrients

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Coarse cereals rich in polyphenols, dietary fiber, and other functional components exert multiple health benefits. We investigated the effects of cooked oats, tartary buckwheat, and foxtail millet on lipid profile, oxido-inflammatory responses, gut microbiota, and colonic short-chain fatty acids composition in high-fat diet (HFD) fed rats. Rats were fed with a basal diet, HFD, oats diet (22% oat in HFD), tartary buckwheat diet (22% tartary buckwheat in HFD), and foxtail millet diet (22% foxtail millet in HFD) for 12 weeks. Results demonstrated that oats and tartary buckwheat attenuated oxidative stress and inflammatory responses in serum, and significantly increased the relative abundance of Lactobacillus and Romboutsia in colonic digesta. Spearman’s correlation analysis revealed that the changed bacteria were strongly correlated with oxidative stress and inflammation-related parameters. The concentration of the butyrate level was elevated by 2.16-fold after oats supplementation. In addition, oats and tartary buckwheat significantly downregulated the expression of sterol regulatory element-binding protein 2 and peroxisome proliferator-activated receptors γ in liver tissue. In summary, our results suggested that oats and tartary buckwheat could modulate gut microbiota composition, improve lipid metabolism, and decrease oxidative stress and inflammatory responses in HFD fed rats. The present work could provide scientific evidence for developing coarse cereals-based functional food for preventing hyperlipidemia.

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Section: Discussionmentioning

confidence: 98%

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Wang

Guo

et al. 2022

Nutrients

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“…There is increasing evidence that the gut microbiota and their catabolites are closely related to gut health [ 41 ]. The composition and structure of the gut microbiota alters in the dysfunctional gut barrier, for example, the abundance of Firmicutes increased and the abundance of Bacteroidetes decreased in intestinal inflammation [ 42 ]. A recent study found that β-glucan improved gut barrier by decreasing the Firmicutes/Bacteroidetes ratio [ 42 ], which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

“…The composition and structure of the gut microbiota alters in the dysfunctional gut barrier, for example, the abundance of Firmicutes increased and the abundance of Bacteroidetes decreased in intestinal inflammation [ 42 ]. A recent study found that β-glucan improved gut barrier by decreasing the Firmicutes/Bacteroidetes ratio [ 42 ], which is consistent with our findings. In addition, we found that β-glucan increased the abundances of Bacteroides , Alloprevotella , Fournierella , Alistipes , and Oscillospira and decreased the abundance of Ruminococcaceae_NK4A214 in feces of the dairy calves.…”

Section: Discussionmentioning

confidence: 99%

“…Bacteroides , Alistipes , and Alloprevotella belonging to Bacteroidetes, and they contribute to the production of short-chain fatty acids (SCFAs) and further benefit gut health [ 43 ]. Beta-glucan is a soluble fiber that can be fermented by the microbiota and produce SCFAs in the gut [ 40 , 42 ]. Similar to Bacteroides, Ruminococcaceae_NK4A214 is a butyrate producer, which plays a positive role in reducing disease risk [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

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Beta-Glucan Alters Gut Microbiota and Plasma Metabolites in Pre-Weaning Dairy Calves

Luo

Zhou

et al. 2022

Metabolites

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The present study aims to evaluate the alterations in gut microbiome and plasma metabolites of dairy calves with β-glucan (BG) supplementation. Fourteen healthy newborn dairy calves with similar body weight were randomly divided into control (n = 7) and BG (n = 7) groups. All the calves were fed on the basal diet, while calves in the BG group were supplemented with oat BG on d 8 for 14 days. Serum markers, fecal microbiome, and plasma metabolites at d 21 were analyzed. The calves were weaned on d 60 and weighed. The mean weaning weight of the BG group was 4.29 kg heavier than that of the control group. Compared with the control group, the levels of serum globulin, albumin, and superoxide dismutase were increased in the BG group. Oat BG intake increased the gut microbiota richness and decreased the Firmicutes-to-Bacteroidetes ratio. Changes in serum markers were found to be correlated with the plasma metabolites, including sphingosine, trehalose, and 3-methoxy-4-hydroxyphenylglycol sulfate, and gut microbiota such as Ruminococcaceae_NK4A214, Alistipes, and Bacteroides. Overall, these results suggest that the BG promotes growth and health of pre-weaning dairy calves by affecting the interaction between the host and gut microbiota.

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“…The effect of whole-grain components on regulating the gut microbiota is summarized in Table 1. For instance, intake of oat β-glucan significantly ameliorated the clinical features of ulcerative colitis in mice, attenuating the severe colonic inflammatory status and improving colonic mucosal barrier function concurrently with regulating gut-derived SCFAs and intestinal microbial metabolic profiles [24]. According to the authors, the reversed expression levels of zonula occludens-1 (ZO-1), occludin, claudin-1, and claudin-4 indicated that oat β-glucan promoted tight junction protein formation and restored intestinal epithelial barrier function.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota

Ren

Fan

Teng

et al. 2021

Foods

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In recent years, chronic diseases including obesity, diabetes, cancer, cardiovascular, and neurodegenerative disorders have been the leading causes of incapacity and death globally. Increasing evidence suggests that improvements of lifestyle habits and diet is the most commonly adopted strategy for the prevention of chronic disorders. Moreover, many dietary compounds have revealed health-promoting benefits beyond their nutritional effects. It is worth noting that diet plays an important role in shaping the intestinal microbiota. Coarse cereals constitute important sources of nutrients for the gut microbiota and contribute to a healthy gut microbiome. Furthermore, the gut microbiota converts coarse cereals into functional substances and mediates the interaction between the host and these components. In this study, we summarize the recent findings concerning functional components of cereal grains and their potential chemopreventive activity via modulating the gut microbiota.

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Oat β-glucan alleviates DSS-induced colitisviaregulating gut microbiota metabolism in mice

Abstract: Oat β-glucan supplementation ameliorated DSS-induced colitis concurrently through regulating gut-derived SCFAs and intestinal microbial metabolic profiles.

Cited by 42 publications

References 57 publications

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Beta-Glucan Alters Gut Microbiota and Plasma Metabolites in Pre-Weaning Dairy Calves

The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota

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