O58 Is the low FODMAP diet effective in the long term? The largest multicentre prospective study

Rej, Anupam; Buckle, Rachel Louise; Shaw, Christian Charles; Trott, Nick; Adu-Tei, Sebastian; Agrawal, Anurag K.; Mosey, Joanna; Sanders, K; Allen, Rupert; Martin, Sophie; Newton, Aimee; Robinson, Kelly; Elphick, David; Aziz, Imran; Sanders, David S.

doi:10.1136/gutjnl-2020-bsgcampus.58

Cited by 1 publication

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“…Zar et al reported that IgG4 antibodies to foods, such as milk, eggs, wheat, beef, pork, and lamb, were elevated in patients with IBS, and a food-specific IgG4 antibody-guided exclusion diet could improve symptoms (Zar et al, 2005). Dietary modifications can improve IBS symptoms (Rej et al, 2022), but gluten-free diet is not more efficient than lowfermentable oligosaccharides, disacchardies, monosaccharides and polyols (FODMAP)-diet (Dionne et al, 2018), and traditional dietary is recommended as first-choice dietary therapy due to its convenience and minimum cost (Rej et al, 2022).…”

Section: Autoantibodies Documented In Ibs Patientsmentioning

confidence: 99%

Role of autoantibodies in the pathophysiology of irritable bowel syndrome: a review

Zhang,

Liao,

Fan

2024

Front. Physiol.

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Irritable bowel syndrome (IBS) is a chronic, recurrent disorder that is characterized by abdominal pain associated with defecation. IBS was previously considered to manifest without any structural alterations until the discovery of post-infection IBS. An increasing body of published evidence indicates that immune activation plays an important role in the development of IBS. Nevertheless, the pathophysiology of IBS, including mainly visceral hypersensitivity and gastrointestinal dysmotility, has not yet been explicitly elucidated. The observation of potential inflammatory degenerative neuropathy, including neuronal degeneration, spearheaded research on autoimmune responses targeting the enteric nervous system. Subsequently, several autoantibodies were detected in the sera of IBS patients, among which some were presumed to exert a pathogenic influence or be associated with the etiology of gastrointestinal dysmotility in IBS. Moreover, certain specific autoantibodies evidently served as biomarkers to facilitate the differentiation between IBS and other related diseases. Therefore, we aimed to present an overview of autoantibodies reported in the sera of IBS patients and highlight their significance in diagnosing and comprehending the pathophysiology of IBS. Consequently, we propose a therapeutic strategy from an autoimmune perspective.

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