[O4–06–01]: Sp1‐modulating Compounds as a Novel Drug Target for Alzheimer's Disease (Ad)

Bayon, Baindu L.; Maloney, Bryan; Chopra, Nipun; White, Fletcher A.; Xu, Xiao–Ming; Ratan, Rajiv R.; Lahiri, Debomoy K.

doi:10.1016/j.jalz.2017.07.448

Cited by 1 publication

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“…It further proposes that overproduction of amyloid precursor protein (APP) and amyloid beta in late life may be triggered by early-life changes to the methylation status of promoters for APP and other related genes ( Lahiri et al, 2007 ). Their group has also proposed epigenetic therapies such as mithramycin and tolfenamic acid to target amyloid pathways; these have been shown to exhibit downstream impact on neuronal structures including cell body, neurite length, and branch points ( Bayon et al, 2017 ). Though AD is an age-related disease, emphasis must be placed on further understanding how early-life and mid-life environments and exposures influence AD risk in later-life stages.…”

Section: Intersection Of Social Determinants and Epigenetics Over Thementioning

confidence: 99%

Understanding the Interplay Between Health Disparities and Epigenomics

et al. 2020

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Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.

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Section: Intersection Of Social Determinants and Epigenetics Over Thementioning

confidence: 99%