O4‐05‐03: Circulating Adiponectin Levels and Its Association With Alzheimer's, Dementia, and Stroke

Shafique, Kashif; Ishtiaque, Afra; Arain, Zain Islam

doi:10.1016/j.jalz.2014.04.411

Cited by 2 publications

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“…However, hormone resistance may prevent the body from getting benefit from this protective increase in adiponectin levels [20]. Shafique K et al, [33] stated that high levels of adiponectin detected in patients with dementia may be due to underlying vascular or morphological dysfunction that may arise as an explanation to the underlying pathophysiology of dementia. On the contrary, Kitagawa K et al [34], failed to confirm the correlation between dementia an adiponectin between adiponectin in 466 studied patients of both genders.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum Levels of Adiponectin and Leptin in a cohort of elderly Egyptian Patients with Dementia

Saad

mehanna

Hanna

et al. 2021

NILES journal for Geriatric and Gerontology

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Background/Aim: Dementia is a chronic progressive deterioration of cognitive function. About 50 million cases of dementia worldwide, 5-8% of elders aged 60 years and more have dementia. Adiponectin is an adipokine and presents in the humans' brains and is linked to multiple functions in the central nervous system. Leptin is a cytokine that was thought to be associated with a decline in cognitive function. The present study aimed to assess adiponectin and leptin levels in elderly demented patients. Materials and methods: the current study included 60 subjects of both genders aged 65 years and more; Group (I): 40 patients with dementia, and Group (II): 20 healthy control subjects. We excluded participants with chronic renal or hepatic diseases, diabetics, hypertensive, dyslipidemic patients, those with thyroid disorders, and those who were morbidly obese. MMSE and MOCA tests were done on all subjects, levels of adiponectin and leptin were assessed in participants' sera using the ELISA test. Results: Higher levels of adiponectin, but low levels of leptin were detected in patients with dementia. MMSE and MOCA scores were significantly correlated with serum adiponectin (negatively), and with serum leptin (positively). Conclusion: In elderly patients with dementia, serum adiponectin and leptin were strongly associated with the degree of dementia, which may help us to understand the underlying pathophysiology of this untreatable disease.

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Section: Discussionmentioning

confidence: 99%

Assessment of serum Levels of Adiponectin and Leptin in a cohort of elderly Egyptian Patients with Dementia

Saad

mehanna

Hanna

et al. 2021

NILES journal for Geriatric and Gerontology

View full text Add to dashboard Cite

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Role of Adiponectin in Central Nervous System Disorders

et al. 2018

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Adiponectin, the most abundant plasma adipokine, plays an important role in the regulation of glucose and lipid metabolism. Adiponectin also possesses insulin-sensitizing, anti-inflammatory, angiogenic, and vasodilatory properties which may influence central nervous system (CNS) disorders. Although initially not thought to cross the blood-brain barrier, adiponectin enters the brain through peripheral circulation. In the brain, adiponectin signaling through its receptors, AdipoR1 and AdipoR2, directly influences important brain functions such as energy homeostasis, hippocampal neurogenesis, and synaptic plasticity. Overall, based on its central and peripheral actions, recent evidence indicates that adiponectin has neuroprotective, antiatherogenic, and antidepressant effects. However, these findings are not without controversy as human observational studies report differing correlations between plasma adiponectin levels and incidence of CNS disorders. Despite these controversies, adiponectin is gaining attention as a potential therapeutic target for diverse CNS disorders, such as stroke, Alzheimer's disease, anxiety, and depression. Evidence regarding the emerging role for adiponectin in these disorders is discussed in the current review.

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O4‐05‐03: Circulating Adiponectin Levels and Its Association With Alzheimer's, Dementia, and Stroke

Cited by 2 publications

References 0 publications

Assessment of serum Levels of Adiponectin and Leptin in a cohort of elderly Egyptian Patients with Dementia

Assessment of serum Levels of Adiponectin and Leptin in a cohort of elderly Egyptian Patients with Dementia

Role of Adiponectin in Central Nervous System Disorders

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