O2‐08‐05: Combined aerobic‐strength exercise improves cognitive functions in patients with mild cognitive impairment

Ukropcová, Barbara; Slobodová, Lucia; Vajda, Matej; Krumpolec, Patrik; Tirpáková, Veronika; Vallova, Silvia; Šutovský, Stanislav; Turčãni, Peter; Sedliak, Milan; Ukropec, Jozef

doi:10.1016/j.jalz.2015.07.175

Cited by 3 publications

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“…However, the mechanisms and determinants of the interplay between neurodegeneration and metabolism are unexplored. A sedentary lifestyle and chronic energy overload are common denominators of neurodegeneration and metabolic impairment ( 43 ), promoting chronic inflammation and insulin resistance, both at the whole-body level and in the brain ( 13 , 44 ). In our study, we observed increased peripheral IR in PD patients, pointing at systemic metabolic dysfunction in PD compared to age/BMI-matched controls, which was alleviated by exercise.…”

Section: Discussionmentioning

confidence: 99%

Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson’s Disease Patients

et al. 2017

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Regular exercise ameliorates motor symptoms in Parkinson’s disease (PD). Here, we aimed to provide evidence that exercise brings additional benefits to the whole-body metabolism and skeletal muscle molecular and functional characteristics, which might help to explain exercise-induced improvements in the clinical state. 3-months supervised endurance/strength training was performed in early/mid-stage PD patients and age/gender-matched individuals (n = 11/11). The effects of exercise on resting energy expenditure (REE), glucose metabolism, adiposity, and muscle energy metabolism (31P-MRS) were evaluated and compared to non-exercising PD patients. Two muscle biopsies were taken to determine intervention-induced changes in fiber type, mitochondrial content, and expression of genes related to muscle energy metabolism, as well as proliferative and regenerative capacity. Exercise improved the clinical disability score (MDS-UPDRS), bradykinesia, balance, walking speed, REE, and glucose metabolism and increased muscle expression of energy sensors (AMPK). However, the exercise-induced increase in muscle mass/strength, mitochondrial content, type II fiber size, and postexercise phosphocreatine (PCr) recovery (31P-MRS) were found only in controls. Nevertheless, MDS-UPDRS was associated with muscle AMPK and mechano-growth factor (MGF) expression. Improvements in fasting glycemia were positively associated with muscle function and the expression of Sirt1 and Cox7a1, and the parameters of fitness/strength were positively associated with the expression of MyHC2, MyHC7, and MGF. Moreover, reduced bradykinesia was associated with better muscle metabolism (maximal oxidative capacity and postexercise PCr recovery; 31P-MRS). Exercise training improved the clinical state in early/mid-stage Parkinson’s disease patients, including motor functions and whole-body metabolism. Although the adaptive response to exercise in PD was different from that of controls, exercise-induced improvements in the PD clinical state were associated with specific adaptive changes in muscle functional, metabolic, and molecular characteristics.Clinical Trial Registration, identifier NCT02253732.

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Section: Discussionmentioning

confidence: 99%

Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson’s Disease Patients

et al. 2017

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“…In their study, Ukropcova et al [27] reported that integrated aerobic-muscular exercise improved cognitive and muscular functions in patients with mild cognitive impairment (MCI). Ngandu et al [12] developed the FINGER program for elderly people at risk of developing dementia, which includes physical exercise, cognitive training, diet control, and social training, that is, multidomain interventions that could improve or maintain the cognitive functions of such elderly patients with dementia.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Activity Programs on the Improvement of Dementia Symptom: A Meta-Analysis

Lee

Park

2016

BioMed Research International

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Objective. To confirm that physical activity program improves the symptoms of dementia and the most effective physical activity was selected to help establish exercise programs. Methods. Three databases, PubMed, Science Direct, and Willey online, were used to collect articles. The databases were published between January 2005 and December 2015. Keywords such as “dementia,” and “physical activity” were used in searching for papers. As a result, nine studies were selected in the second screening of the meta-analyses. Results. The improvement in the dementia symptom of physical capacity was 1.05 (high effect size, 95% CI: 0.03 to 0.73), ability of activity of daily living was 0.73 (slightly high effect size, 95% CI: 0.23 to 1.23), cognitive function was 0.46 (medium effect size, 95% CI: 0.26 to 0.66), and psychological state was 0.39 (lower than the medium effect size, 95% CI: 0.01 to 0.77). Conclusion. The physical activity for patients with dementia had an effect on the improvement of physical capacity and combined exercise was the most effective physical activity.

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Efectividad de un programa de fisioterapia multimodal en la capacidad funcional y emocional de adultos mayores con discapacidad intelectual severa

Otaegui¹

2020

RIAA

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Antecedentes: El aumento de la esperanza de vida de las personas con discapacidad intelectual severa acelera un proceso de envejecimiento prematuro que favorece la presencia de un proceso de fragilidad física y psicológica que afecta a la calidad de vida. Objetivos: Este estudio pretende investigar los efectos de una intervención de fisioterapia multimodal en la capacidad funcional de adultos mayores con discapacidad intelectual. Este estudio se realizó durante seis meses y consistió en la realización de sesiones de masoterapia adaptada, ejercicio físico terapéutico en un entorno natural y fisioterapia acuática. Método: Ensayo clínico controlado aleatorizado. Los criterios de inclusión fueron ser mayores de 50 años, presentar diagnóstico de discapacidad intelectual severa teniendo en cuenta los criterios de la DSM-V y presentar alto riesgo de presentar demencias según el NTG-EDSD. Los participantes fueron asignados al azar en el grupo experimental y en el grupo control. Las variables físicas se midieron por medio del Test de Alusti Abreviado, 10MWT, 6MWT, TUG, SCPT, las variables psicológicas por medio del NPI-Q y las variables relacionadas con la calidad de vida por medio del QUALID. Resultados: La muestra final estuvo compuesto por 20 adultos mayores, de los cuales 10 formaron parte del grupo experimental en el cual se obtuvieron diferencias significativas con una p inferior a 0,005, una mejoría en la movilidad (16,5%), en la potencia muscular de la extremidad inferior (90,2%), en el equilibrio dinámico (7,2%), en la capacidad cardio-respiratoria (19,3%), en la velocidad de la marcha (19,4%), en la disminución de los síntomas neuropsiquiátricos (54,45%) y en la mejoría de la calidad de vida (57,8%). Conclusiones: La intervención de fisioterapia multimodal basada en la combinación de sesiones de terapia manual, sesiones de ejercicio físico en un circuito al aire libre y las sesiones de fisioterapia acuática del programa AquaCap fue capaz de mejorar la capacidad funcional, disminuir los síntomas neuropsiquiátricos mejorando la capacidad de expresión emocional y mejorar la calidad de vida de adultos mayores con discapacidad intelectual grave con alto riesgo de demencias. Palabras clave: terapia manual, ejercicio físico, fisioterapia acuática, demencia.

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O2‐08‐05: Combined aerobic‐strength exercise improves cognitive functions in patients with mild cognitive impairment

Cited by 3 publications

References 0 publications

Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson’s Disease Patients

Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson’s Disease Patients

Effects of Physical Activity Programs on the Improvement of Dementia Symptom: A Meta-Analysis

Efectividad de un programa de fisioterapia multimodal en la capacidad funcional y emocional de adultos mayores con discapacidad intelectual severa

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