O05Cabergoline for lactation inhibition after second-trimester abortion or loss: A randomized controlled trial

Henkel, Andrea; Sa, Johnson; Cahill, EP; Matthew, RF; Blumenthal, P.; Shaw, KA

doi:10.1016/j.contraception.2022.09.010

Cited by 3 publications

(3 citation statements)

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“…Breast symptoms (engorgement, tenderness, milk leakage) after second-trimester pregnancy loss or termination are common, but pharmacotherapy to suppress engorgement and lactation is limited. In a randomized placebo-controlled trial of approximately 70 patients with pregnancy loss or termination at 18 to 26 weeks of gestation, cabergoline (1 mg orally within four hours of fetal expulsion/extraction) substantially reduced breast symptoms on days 2 through 14 of follow-up 2. Side effects were similar between groups, but the trial was not powered to detect small differences.…”

Section: Obstetrics and Gynecology — Office Gynecologymentioning

confidence: 99%

UpToDate®

2023

The Nurse Practitioner

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Section: Obstetrics and Gynecology — Office Gynecologymentioning

confidence: 99%

UpToDate®

2023

The Nurse Practitioner

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“…Lactation may occur as early as after an abortion in weeks 14–16. Drugs for inhibition of lactation include bromocriptine given for 10 days or cabergoline given within 24 h of complete abortion [23 ▪▪ ]. It is important that patients women are made aware of possible lactation occurring and how they can prevent it e.g.…”

Section: Inhibition Of Lactation After Second Trimester Medical Abortionmentioning

confidence: 99%

Medical abortion in the second trimester – an update

Kopp Kallner

2023

Current Opinion in Obstetrics &Amp; Gynecology

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The safety and efficacy of medical abortion in the second trimester is provider independent and may therefore offer advantages over surgical second trimester abortion in certain settings. Due to bleeding risk, medical abortions in the second trimester are still mostly performed in a clinic or hospital setting. The most effective regimen for abortion includes pretreatment with oral mifepristone and following doses of misoprostol. An alternative is misoprostol only which should only be used when mifepristone is not available. The optimal dosing of prostaglandin to achieve the highest efficacy with the lowest proportion of complications remains to be established. Complications are rare and serious adverse events uncommon but may include uterine rupture especially in women with a previous cesarean delivery or uterine surgery. Women having second trimester medical abortion are a diverse group with different indications for the abortion. All women should be offered pain relief and respectful care. Staff involved in second trimester medical abortion often find their work challenging. At the same time, staff indicate pride and a conviction of contributing to the ‘greater good’ for women and society. Staff involved in second trimester abortion should be offered guidance and support through the employer. Post abortion contraception should be offered to all women having second trimester medical abortions, including those who have the abortion due to fetal malformation. All methods of contraception can be started immediately after a second trimester medical abortion except for cycle based methods and diaphragms.

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“…Data related to persons attempting to reduce breast engorgement or suppress lactation after second-trimester abortion is limited. Henkel et al 40 demonstrated in a randomized, placebo-controlled trial that a single 1 mg dose of cabergoline administered 4 hours before the abortion is effective for preventing breast symptoms and is well tolerated by patients.…”

Section: Postprocedural Considerationsmentioning

confidence: 99%

Second-trimester Abortion

Swantic,

Hawley,

Zipp

et al. 2023

Clinical Obstetrics &Amp; Gynecology

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In 2019, the US Centers for Disease Control reported that 7% of abortions were performed after 13 weeks of pregnancy, a small proportion of all terminations. However, the need for second-trimester abortions will increase commensurate with restrictions to access nationwide. Second-trimester abortions are performed with medications or through a procedure. Health care practitioners serving persons at risk of pregnancy should understand how abortions are performed and how to deliver evidence-based postabortion care. The purpose of this article is to provide a foundation for caring for individuals before, during, and after second-trimester abortion.

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O05Cabergoline for lactation inhibition after second-trimester abortion or loss: A randomized controlled trial

Cited by 3 publications

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UpToDate®

UpToDate®

Medical abortion in the second trimester – an update

Second-trimester Abortion

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