Abstract:Introduction Macrophage activation syndrome (MAS) is a severe condition, which can appear as a complication of inflammatory rheumatic diseases such as systemic juvenile idiopathic arthritis (sJIA) and adult onset Still's disease (AOSD), a viral infection, or a malignancy. Interleukin (IL)À18 is a proinflammatory cytokine of the IL-1 family, known as a strong interferon (IFN)-g inducer, that is naturally inhibited by IL-18 binding protein (IL-18BP). High levels of unbound biologically active IL-18 have been des… Show more
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