O01.8 Contemporary syphilis is characterised by rapid global spread of pandemic Treponema pallidum lineages

Beale, MA; Marks, Michael; Mj, Cole; M, Lee; Pitt, Rachel; Ruis, Chris; Balla, Eszter; Crucitti, Tania; Ewens, Michael; Fernández‐Naval, Candela; Grankvist, Anna; Guiver, Malcolm; Cr, Kenyon; Khairulin, Rafil; Kularatne, Ranmini; Arando, Maider; Bj, Molini; Обухов, А. П.; Ee, Page; Petrovay, Fruzsina; Rietmeijer, Cornelis A.; Rowley, David; Shokoples, Sandy; Smit, Erasmus; El, Sweeney; Taiaroa, George; Jh, Vera; Wennerås, Christine; Dm, Whiley; Da, Williamson; Hughes, G.; Naidu, Prenilla; Unemo, Magnus; Krajden, Mel; Sa, Lukehart; Mg, Morshed; Fifer, Helen; Nr, Thomson

doi:10.1136/sextrans-2021-sti.55

Cited by 5 publications

(3 citation statements)

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“…With the current knowledge, the unique TP strains within countries ( 6 , 11 – 13 , 15 ) seem to suggest local transmission besides international mixing as was also found in this study with 8/14 (57%) allelic profiles occurring only once. The 20% prevalence of TP strains belonging to the Nichols lineage in this study is similar to previous studies in Amsterdam ( 11 ), Japan ( 16 ), and Argentina ( 17 ), and is comparable with a recent large-scale genomic study of samples from 23 countries ( 18 ). However, a large older study on 970 publicly available sequences described that 93.5% belonged to the SS14 lineage ( 19 ) and some countries showed <10% circulating Nichols strains, such as in the Czech Republic ( 12 ), France ( 13 ), and Switzerland ( 6 ).…”

Section: Discussionsupporting

confidence: 91%

Treponema pallidum Subspecies Pallidum Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis

et al. 2022

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Section: Discussionsupporting

confidence: 91%

Treponema pallidum Subspecies Pallidum Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis

et al. 2022

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“… 5 However, a temporal increase of MRAM has been reported before in TPA isolates. 5 , 9 Macrolide resistance-associated mutation was present in all 7 successfully determined samples from Antwerp, in concordance with a previous study. 10 …”

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confidence: 91%

“…The 90% MRAM rate among this population is higher than in samples from 2006–2018 among mostly MSM in Amsterdam, where 81% of the samples contained a MRAM 5 . However, a temporal increase of MRAM has been reported before in TPA isolates 5,9 . Macrolide resistance-associated mutation was present in all 7 successfully determined samples from Antwerp, in concordance with a previous study 10 …”

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confidence: 89%

Treponema pallidum Strains Among Women and Men Who Have Sex With Women in Amsterdam, the Netherlands and Antwerp, Belgium Between 2014 and 2020

et al. 2023

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Genome sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

Lieberman

Lin

Xie

et al. 2021

Preprint

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In spite of its immutable susceptibility to penicillin, Treponema pallidum ( T. pallidum ) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective vaccine to curtail the spread of the infection. Several technical challenges, including absence of an in vitro culture system until very recently, have hampered efforts to catalog the diversity of strains collected worldwide. Here, we provide near-complete genomes from 196 T. pallidum strains – including 191 T. pallidum subsp. pallidum – sequenced directly from patient samples collected from 8 countries and 6 continents. Maximum likelihood phylogeny revealed that samples from most sites were predominantly SS14 clade. However, 99% (84/85) of the samples from Madagascar formed two of the five distinct Nichols subclades. Although recombination was uncommon in the evolution of modern circulating strains, we found multiple putative recombination events between T. pallidum subsp. pallidum and subsp. endemicum , shaping the genomes of several subclades. Temporal analysis dated the most recent common ancestor of Nichols and SS14 clades to 1717 (95% HPD: 1543-1869), in agreement with other recent studies. Rates of SNP accumulation varied significantly among subclades, particularly among different Nichols subclades, and was associated in the Nichols A subclade with a C394F substitution in TP0380, a ERCC3-like DNA repair helicase. Our data highlight the role played by variation in genes encoding putative surface-exposed outer membrane proteins in defining separate lineages, and provide a critical resource for the design of broadly protective syphilis vaccines targeting surface antigens.

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O01.8 Contemporary syphilis is characterised by rapid global spread of pandemic Treponema pallidum lineages

Cited by 5 publications

References 0 publications

Treponema pallidum Subspecies Pallidum Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis

Treponema pallidum Subspecies Pallidum Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis

Treponema pallidum Strains Among Women and Men Who Have Sex With Women in Amsterdam, the Netherlands and Antwerp, Belgium Between 2014 and 2020

Genome sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

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