2021
DOI: 10.1002/ange.202109566
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O2‐Assisted Four‐Component Reaction of Vinyl Magnesium Bromide with Chiral Ntert‐Butanesulfinyl Imines To Form syn‐1,3‐Amino Alcohols

Abstract: An O 2 -assisted, four-component reaction has been developed to synthesizeawide range of syn-1,3-amino alcohols in one step.T he reaction proceeds by oxygenation of vinyl magnesium bromide (component-I) with O 2 (component-II) to give am agnesium enolate of acetaldehyde,w hich undergoes addition to ac hiral N-tert-butanesulfinyl imine (component-III) followed by asequential addition with excess vinyl magnesium bromide (component-IV). The approach allows diastereoselective synthesis of anti/syn-and syn/syn-3ami… Show more

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