O Rex gloriae

Siebert, F. Mark; Marenzio, Luca; Gabrieli, Giovanni

doi:10.2307/892332

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2019

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“…1, left) well reflects experimental findings (e.g. unpublished evaluation of data from [7]). Thus, it can be concluded that the applied multi-scale model resolves the major properties determining EMD and can be used for an in silico characterization of EMD.…”

Section: Discussionsupporting

confidence: 73%

Simulating electromechanical delay across the scales – relating the behavior of single sarcomers on a sub‐cellular scale and the muscle‐tendon system on the organ scale

Schmid

Klotz

Siebert

et al. 2019

Proc Appl Math and Mech

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The time lag between the activation of a muscle and the development of force is commonly denoted as electromechanical delay (EMD). Within this work, a multi-scale model of an idealized muscle-tendon system is used to analyze EMD on different characteristic anatomical length scales. Thereby, the simluated EMD-stretch curves for a complete muscle-tendon system and a single sarcomere are significantly different. While for an isolated muscle EMD is shown to be strongly determined by excitation-contraction coupling (ECC), the EMD-stretch curve for a complete muscle-tendon system is influenced by additional factors, such as, e.g., the tendon. Further, it is shown that the action potential conduction velocity (APCV) has minor influence on EMD.

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Section: Discussionsupporting

confidence: 73%