O-RADS MRI: A Systematic Review and Meta-Analysis of Diagnostic                     Performance and Category-wise Malignancy Rates

Rizzo, Stefania; Cozzi, Andrea; Dolciami, Miriam; Grande, Filippo Del; Scarano, Angela Lia; Papadia, Andrea; Gui, Benedetta; Gandolfo, Nicoletta; Catalano, Carlo; Manganaro, Lucia

doi:10.1148/radiol.220795

Cited by 21 publications

(9 citation statements)

References 37 publications

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“…As reported by Rizzo et al [ 21 ] MRI 4 assignments are related to the correct interpretation of TIC and the diagnostic performance is influenced by DCE MRI protocol, with a 90% summary specificity among studies where DCE sequences were performed with a 15 s or less temporal resolution (coefficient, 0.4; P = 0.049).…”

Section: Discussionmentioning

confidence: 71%

“…O-RADS MRI scoring system has a high sensitivity and specificity (92% and 91%, respectively) for the evaluation of indeterminate adnexal masses on ultrasound, as reported in a recent meta-analysis [ 21 ] including 13 studies with 4520 adnexal lesions .…”

Section: Discussionmentioning

confidence: 89%

“…In this study, we retrospectively analysed adnexal masses using the O-RADS MRI scoring system described by Thomassin-Naggara et al [9]. O-RADS MRI scoring system has a high sensitivity and specificity (92% and 91%, respectively) for the evaluation of indeterminate adnexal masses on ultrasound, as reported in a recent meta-analysis [21] including 13 studies with 4520 adnexal lesions.…”

Section: Discussionmentioning

confidence: 99%

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Impact of DWI and ADC values in Ovarian-Adnexal Reporting and Data System (O-RADS) MRI score

et al. 2023

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Purpose Introduce DWI and quantitative ADC evaluation in O-RADS MRI system and observe how diagnostic performance changes. Assess its validity and reproducibility between readers with different experience in female pelvic imaging. Finally, evaluate any correlation between ADC value and histotype in malignant lesions. Materials and Methods In total, 173 patients with 213 indeterminate adnexal masses (AMs) on ultrasound were subjected to MRI examination, from which 140 patients with 172 AMs were included in the final analysis. Standardised MRI sequences were used, including DWI and DCE sequences. Two readers, blinded to histopathological data, retrospectively classified AMs according to the O-RADS MRI scoring system. A quantitative analysis method was applied by placing a ROI on the ADC maps obtained from single-exponential DWI sequences. AMs considered benign (O-RADS MRI score 2) were excluded from the ADC analysis. Results Excellent inter-reader agreement was found in the classification of lesions according to the O-RADS MRI score (K = 0.936; 95% CI). Two ROC curves were created to determine the optimal cut-off value for the ADC variable between O-RADS MRI categories 3–4 and 4–5, respectively, 1.411 × 10–3 mm2/sec and 0.849 × 10–3 mm2/sec. Based on these ADC values, 3/45 and 22/62 AMs were upgraded, respectively, to score 4 and 5, while 4/62 AMs were downgraded to score 3. ADC values correlated significantly with the ovarian carcinoma histotype (p value < 0.001). Conclusion Our study demonstrates the prognostic potential of DWI and ADC values in the O-RADS MRI classification for better radiological standardisation and characterisation of AMs.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Impact of DWI and ADC values in Ovarian-Adnexal Reporting and Data System (O-RADS) MRI score

et al. 2023

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“…Using only nine MRI criteria, the model can distinguish benign from malignant adnexal masses with a sensitivity and specificity of over 90%. 1,2 Hence, a radiologist who is familiar with the O-RADS lexicon and step-by-step MRI analysis will be able to correctly classify lesions with high agreement between nonexpert and expert readers (kappa values 0.784-0.904). 1,26 For the expert radiologist, if a pathological hypothesis is made, the O-RADS MRI score could add a degree of certainty.…”

Section: O-rads Mri Score: An Essential But Insufficient Toolmentioning

confidence: 99%

“…T he ovarian-adnexal reporting and data system on magnetic resonance imaging (O-RADS MRI) score is now a well-established tool to characterize pelvic gynecological masses based on their likelihood of malignancy. 1,2 The complexity of managing adnexal masses lies in avoiding underdiagnosis of malignant lesions-implying a bad prognosis and urgent treatment-and overdiagnosis of benign lesions leading to unnecessary surgery and compromising fertility. 3 The prevalence of malignancy in women undergoing ovarian surgery is quite low, especially if surgery is based purely on ultrasonography (US) results, 4 and the risk of infertility after surgery for benign ovarian cysts has been largely demonstrated.…”

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confidence: 99%

O‐RADS MRI SCORE: An Essential First‐Step Tool for the Characterization of Adnexal Masses

Thomassin‐Naggara

Dabi

Florin

et al. 2023

Magnetic Resonance Imaging

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The ovarian‐adnexal reporting and data system on magnetic resonance imaging (O‐RADS MRI) score is now a well‐established tool to characterize pelvic gynecological masses based on their likelihood of malignancy. The main added value of O‐RADS MRI over O‐RADS US is to correctly reclassify lesions that were considered suspicious on US as benign on MRI. The crucial issue when characterizing an adnexal mass is to determine the presence/absence of solid tissue and thus need to perform gadolinium injection. O‐RADS MR score was built on a multivariate analysis and must be applied as a step‐by‐step analysis: 1) Is the mass an adnexal mass? 2) Is there an associated peritoneal carcinomatosis? 3) Is there any significant amount of fatty content? 4) Is there any wall enhancement? 5) Is there any internal enhancement? 6) When an internal enhancement is detected, does the internal enhancement correspond to solid tissue or not? 7) Is the solid tissue malignant? With its high value to distinguish benign from malignant adnexal masses and its high reproducibility, the O‐RADS MRI score could be a valuable tool for timely referral of a patient to an expert center for the treatment of ovarian cancers. Finally, to make a precise diagnosis allowing optimal personalized treatment, the radiologist in gynecological imaging will combine the O‐RADS MRI score with many other clinical, biological, and other MR criteria to suggest a pathological hypothesis.Level of Evidence5Technical Efficacy Stage3.

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Differentiating struma ovarii from FIGO stage I malignant ovarian tumors in O-RADS MRI 5 lesions: a targeted cohort study

Ye,

Zheng,

Pan

et al. 2024

Abdom Radiol

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O-RADS MRI: A Systematic Review and Meta-Analysis of Diagnostic Performance and Category-wise Malignancy Rates

Cited by 21 publications

References 37 publications

Impact of DWI and ADC values in Ovarian-Adnexal Reporting and Data System (O-RADS) MRI score

Impact of DWI and ADC values in Ovarian-Adnexal Reporting and Data System (O-RADS) MRI score

O‐RADS MRI SCORE: An Essential First‐Step Tool for the Characterization of Adnexal Masses

Differentiating struma ovarii from FIGO stage I malignant ovarian tumors in O-RADS MRI 5 lesions: a targeted cohort study

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