O peso do baço em chagásicos crônicos

Pereira, Sanívia Aparecida de Lima; Corrêa, Beatriz Soares; Minicucci, Gisela Paludeto; Lopes, Glauce Marlei Aires; Castro, Eumênia Costa da Cunha; Reis, Marlene Antônia dos; Teixeira, Vicente de Paula Antunes

doi:10.1590/s0037-86821999000200008

Cited by 3 publications

(5 citation statements)

References 6 publications

(2 reference statements)

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“…In an earlier report, 15 we described a significant increase in spleen weight in chagasic cases without congestive heart failure in comparison to nonchagasic cases without congestive heart failure, in groups of Chagas' disease or non-Chagas' disease individuals, with or without congestive heart failure, and homogenized relation to age, sex, color, and body mass index. We concluded that the inflammatory component in Chagas' disease plays an important role in the increase of spleen weight together with hemodynamic alterations arising from congestive heart failure.…”

Section: Discussionmentioning

confidence: 68%

“…Nevertheless, the areas of these follicles, as well as the congestion of the sinusoids, were significantly greater among the chagasic cases. These data apparently indicate that, because of the increase in spleen weight 15 and possibly its size, there would be greater dispersion of the follicles, thus justifying the lesser density. On the other hand, although "a certain degree of atrophy of the follicles" has previously been described in cases of chronic passive hyperemia, 7 hyperplasia of the white 10.3 ± 1.0 Chagasic without CHF (n ‫ס‬ 17)…”

Section: Discussionmentioning

confidence: 92%

“…15 Financial support: This work was supported by research grants from the Fundaçã o de Ensino e Pesquisa de Uberaba (FUNEPU), Funda-çã o de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), and Universidade de Uberaba (UNIUBE).…”

Section: Discussionmentioning

confidence: 99%

“…7 There are few reports of spleen involvement in the chronic phase of Chagas' disease, and they generally refer to thromboembolic phenomena [10][11][12][13][14] or weight alterations. 15 Because Chagas' disease is an infectious disease that has an inflammatory response as one of its basic lesions, with the possibility of presenting hemodynamic repercussions, we raised the hypothesis that alterations capable of objective evaluation via morphometry could exist in these circumstances. Such alterations in the parenchyma and stroma of the spleen would be a result not only of cardiac involvement but also of the infectious process.…”

Section: Introductionmentioning

confidence: 99%

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Morphometric study of the spleen in chronic Chagas' disease.

Pereira

Rodrigues²,

Castro³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphometric study of the spleen in chronic Chagas' disease.

Pereira

Rodrigues²,

Castro³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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“…In experimental T . cruzi infection, splenomegaly is associated with increased polyclonal T-cell activation, a hallmark of not regulated immune response [ 6 , 9 , 38 ]. Notably, the splenomegaly seen in Colombian-infected C57BL/6 mice [ 9 , 15 ] was partially reversed by PTX therapy.…”

Section: Discussionmentioning

confidence: 99%

Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8+ T-Cell Response

et al. 2015

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BackgroundChronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8+ T-cell abnormalities and CD8-enriched myocarditis occurring in an inflammatory milieu. Pentoxifylline (PTX), a phosphodiesterase inhibitor, has immunoregulatory and cardioprotective properties. Here, we tested PTX effects on CD8+ T-cell abnormalities and cardiac alterations using a model of experimental Chagas’ heart disease.Methodology/Principal FindingsC57BL/6 mice chronically infected by the Colombian Trypanosoma cruzi strain and presenting signs of CCC were treated with PTX. The downmodulation of T-cell receptors on CD8+ cells induced by T. cruzi infection was rescued by PTX therapy. Also, PTX reduced the frequency of CD8+ T-cells expressing activation and migration markers in the spleen and the activation of blood vessel endothelial cells and the intensity of inflammation in the heart tissue. Although preserved interferon-gamma production systemically and in the cardiac tissue, PTX therapy reduced the number of perforin+ cells invading this tissue. PTX did not alter parasite load, but hampered the progression of heart injury, improving connexin 43 expression and decreasing fibronectin overdeposition. Further, PTX reversed electrical abnormalities as bradycardia and prolonged PR, QTc and QRS intervals in chronically infected mice. Moreover, PTX therapy improved heart remodeling since reduced left ventricular (LV) hypertrophy and restored the decreased LV ejection fraction.Conclusions/SignificancePTX therapy ameliorates critical aspects of CCC and repositioned CD8+ T-cell response towards homeostasis, reinforcing that immunological abnormalities are crucially linked, as cause or effect, to CCC. Therefore, PTX emerges as a candidate to treat the non-beneficial immune deregulation associated with chronic Chagas' heart disease and to improve prognosis.

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Comparison of Sericins from Different Sources as Natural Therapeutics against Ulcerative Colitis

Zhou

Yang

et al. 2021

ACS Biomater. Sci. Eng.

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Sericin has become a promising natural anti-inflammatory protein. However, the biological functions of sericins largely depend on their origins; no study has yet been carried out to comparatively investigate the therapeutic effects of sericins from different sources against inflammatory diseases. Herein, we extracted and purified three kinds of sericins, namely silkworm sericin (SS), tussah sericin (TS), and castor silk sericin (CSS). These sericins showed negligible cytotoxicities against colitis-associated cells (colon epitheliums and activated macrophages). Further investigations displayed that these sericins could remarkably downregulate the secreted amounts of TNF-α, promote the recovery of the damaged colonic epithelial barrier, and eliminate endogenous reactive oxygen species in Raw 264.7 macrophages and Caenorhabditis elegans. In vivo experiments demonstrated that chitosan/alginate hydrogel-encapsulating SS could achieve efficient accumulation of SS in the colitis tissues and thereby play a more effective role in relieving ulcerative colitis (UC) than TS and CSS. Our findings collectively demonstrate that SS can be extracted, formulated, and used as a robust therapeutic agent for the oral treatment of UC.

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O peso do baço em chagásicos crônicos

Abstract: Resumo O baço pode aumentar de tamanho nas inflamações com repercussões sistêmicas e na congestão venosa crônica, denominando-se respectivamente, hiperplasia reacional e e s p l e n o m e g a l i a congestiva.

Cited by 3 publications

References 6 publications

Morphometric study of the spleen in chronic Chagas' disease.

Morphometric study of the spleen in chronic Chagas' disease.

Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8+ T-Cell Response

Comparison of Sericins from Different Sources as Natural Therapeutics against Ulcerative Colitis

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