“…In an unselected series a tertiary pattern was seen in 48% of cases, 73 while in another study only 13% of cases had a tertiary component if consideration was limited to tumours of a higher grade than that of the primary and secondary pattern and <5% of tumour volume. 38 In various series of radical prostatectomy specimens the presence of a tertiary pattern was associated more frequently with PSA recurrence, [65][66][67][68]71,73 extraprostatic extension, 65,69,73 surgical margin positivity, 65,69,70,73 seminal vesicle infiltration 65,66,69,73 and lymph node metastases. 65,66,69,72 When cases were stratified according to < or ‡5% of tumour volume, an association with extraprostatic extension, positive surgical margin, seminal vesicle invasion and lymph node infiltration was observed only in the ‡5% group.…”