O óleo de chaulmoogra como conhecimento científico: a construção de uma terapêutica antileprótica

Abstract

Analisa os processos de assimilação e transformação de saberes e práticas terapêuticas que envolvem o uso de plantas medicinais, e destaca o uso, no combate à lepra, do óleo da chaulmoogra. Atenta para os diferentes modos de incorporação e transformação das chaulmoogras em conhecimentos validados cientificamente, tendo em vista a entrada em cena da 'chaulmoogra brasileira'. Privilegia a chegada dos derivados dessa planta à pauta de produção do Instituto Oswaldo Cruz (IOC), na década de 1920, estabelecendo nexos entre os diferentes processos produtivos e articulando-os ao contexto científico no período estudado. O óleo de chaulmoogra representou, até a década de 1940, a grande esperança para a tentativa de cura da lepra. Observa ainda que a terapêutica chaulmúgrica durante esse período, consolidou-se como um saber científico graças à realização de diversas pesquisas feitas em laboratórios de todo o mundo ocidental.

Lepra: doença, isolamento e segregação no contexto colonial em Moçambique

“…However, they were not all so liberal in practice. Firmino Sant'Anna (1924) argued that the constitution of "racially homogeneous" groups should extend out beyond the leper community and be applied to the whole colonial population, especially in the towns. He held that while the "absolute community of races" might constitute the "highest expression of a spirit of justice and equity for the subjugated," it would be an "error of catastrophic repercussions."…”

Development of solid lipid nanoparticle gel for transdermal delivery system of chaulmoogra oil

“…The NMR of the isolated constituent was taken by dissolving it in dimethyl sulfoxide (DMSO). 1 H-NMR and 13 C-NMR showed different peaks for different types of protons and 13 C present in the structure of HA [12]. DSC DSC thermogram was obtained in the temperature range of 40°-400°C at 15°C/min rate on the Pyris 6 DSC instrument and the scan was obtained [13].…”

“…Chaulmoogra oil (CMO) is a fixed oil derived from the seeds of the Hydnocarpus whightana, H. anthelmintica, and Taractogenose kurzii belonging to the family Flacourtiaceae [1]. The oil contains naturally occurring cyclopentenyl fatty acid as hydnocarpic acid (HA), the bioactive principle acting as an anti-leprotic agent [2].…”

From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

“…The natural antileprotic product derived from plants most cited in the literature is the chaulmoogra oil. Chaulmoogras are angiospermic plants and include the Hydnocarpus, Carpotroche, Caloncoba, Oncoba, Lindackeria, and Mayna genus [213]. Chaulmoogras are angiospermic plants and include the Hydnocarpus, Carpotroche, Caloncoba, Oncoba, Lindackeria, and Mayna genus [213].…”