O'nyong-nyong fever: An epidemic virus disease in East Africa 1. Introduction

Haddow, A. J.; Davies, C.W.; Walker, A. J.

doi:10.1016/0035-9203(60)90025-0

Cited by 79 publications

(55 citation statements)

References 4 publications

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“…However this type of arthritis follows 2 to 4 weeks after vaccination, and none of these patients was vaccinated within 1 year of the onset of arthritis. Three group A arboviruses-chikungunya, o'nyong-nyong, and Ross River-all transmitted through mosquito vectors, have been reported to cause primarily arthritis, in epidemic proportions (33)(34)(35)(36)(37). However chikungunya and o'nyong-nyong arthritides are dengue-like illnesses that typically affect large joints symmetrically, epidemic polyarthritis in Australia caused by the Ross River virus usually affects small joints in the hands, and none of the three has been reported to recur.…”

Section: Discussionmentioning

confidence: 99%

An epidemic of oligoarticular arthritis in children and adults in three connecticut communities

Steere

Malawista

Snydman

et al. 1977

Arthritis & Rheumatism

1,106

437

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An epidemic form of arthritis has been occurring in eastern Connecticut at least since 1972, with the peak incidence of new cases in the summer and early fall. Its identification has been possible because of tight geographic clustering in some areas, and because of a characteristic preceding skin lesion in some patients. The authors studied 51 residents of three contiguous Connecticut communities—39 children and 12 adults—who developed an illness characterized by recurrent attacks of asymmetric swelling and pain in a few large joints, especially the knee. Attacks were usually short (median: 1 week) with much longer intervening periods of complete remission (median: 2.5 months), but some attacks lasted for months. To date the typical patient has had three recurrences, but 16 patients have had none. A median of 4 weeks (range: 1–24) before the onset of arthritis, 13 patients (25%) noted an erythematous papule that developed into an expanding, red, annular lesion, as much as 50 cm in diameter. Only 2 of 159 family members of patients had such a lesion and did not develop arthritis (P < 0.000001). The overall prevalence of the arthritis was 4.3 cases per 1,000 residents, but the prevalence among children living on four roads was 1 in 10. Six families had more than 1 affected member. Nine of 20 symptomatic patients had low serum C3 levels, compared to none of 31 asymptomatic patients (P < 0.005); no patient had iridocyclitis or a positive test for antinuclear antibodies. Neither cultures of synovium and synovial fluid nor serologic tests were positive for agents known to cause arthritis. “Lyme arthritis” is thought to be a previously unrecognized clinical entity, the epidemiology of which suggests transmission by an arthropod vector.

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Section: Discussionmentioning

confidence: 99%

An epidemic of oligoarticular arthritis in children and adults in three connecticut communities

Steere

Malawista

Snydman

et al. 1977

Arthritis & Rheumatism

1,106

437

View full text Add to dashboard Cite

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“…[1][2][3][4][5][6] O'nyong-nyong virus has caused three major outbreaks of disease in Africa. [7][8][9][10] The first occurred in Uganda in the late 1950s and early 1960s and affected over 2 million people. 7 The last two outbreaks occurred in 1996 and 2003, affecting tens of thousands of people.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10] The first occurred in Uganda in the late 1950s and early 1960s and affected over 2 million people. 7 The last two outbreaks occurred in 1996 and 2003, affecting tens of thousands of people. [8][9][10][11] O'nyong-nyong virus causes a similar syndrome to CHIKV, Ross River virus (RRV), and other Old World arthritic alphaviruses, characterized by fever, rash, debilitating arthralgia, and myalgia.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] O'nyong-nyong virus causes a similar syndrome to CHIKV, Ross River virus (RRV), and other Old World arthritic alphaviruses, characterized by fever, rash, debilitating arthralgia, and myalgia. [7][8][9][10][11] The disease is self-limiting and lasts a few days, though some patients have more persistent arthrlagia. 12 In contrast to CHIKV, which has recently been shown to produce neurologic manifestations and death in some individuals, ONNV is not known to cause fatal disease.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Innate versus Adaptive Immune Responses in a Mouse Model of O'Nyong-Nyong Virus Infection

Seymour

Rossi

Bergren

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. O'nyong-nyong virus (ONNV), an alphavirus closely related to chikungunya virus (CHIKV), has caused three major epidemics in Africa since 1959. Both ONNV and CHIKV produce similar syndromes with fever, rash, and debilitating arthralgia. To determine the roles of the innate and adaptive immune responses, we infected different knockout mice with two strains of ONNV (SG650 and MP30). Wild-type, RAG1 KO, and IFNγR KO mice showed no signs of illness or viremia. The STAT1 KO and A129 mice exhibited 50-55% mortality when infected with SG650. Strain SG650 was more virulent in the STAT1 KO and A129 than MP30. Deficiency in interferon α/β signaling (A129 and STAT1 KO) leaves mice susceptible to lethal disease; whereas a deficiency of interferon γ signaling alone had no effect on survival. Our findings highlight the importance of type I interferon in protection against ONNV infection, whereas the adaptive immune system is relatively unimportant in the acute infection.

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“…funestus, [3][4][5] has been involved in large scale epidemics in Africa. [6][7][8] Although no fatalities occurred, the 1959-1962 epidemic involved more than two million cases. 3,4 In 1996, ONNV was the cause of another epidemic in Uganda after an absence of 35 years.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Vector Specificity of O’nyong Nyong and Chikungunya Viruses in Anopheles and Aedes Mosquitoes

Vanlandingham¹,

Tsetsarkin²,

Klingler³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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Abstract. The alphaviruses o'nyong nyong virus (ONNV) and chikungunya virus (CHIKV) provide a unique system to study the viral genes involved in vector specificity. ONNV infects both anopheline and culicine mosquitoes, whereas CHIKV infects only culicine mosquitoes. In this study, chimeric viruses were constructed that contained genes from both ONNV and CHIKV. These chimeras and previously described full-length infectious clones of ONNV and CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes. Virus derived from the infectious clones of ONNV and CHIKV retained the vector specificity of the parental viruses. All six of the chimeras were found to infect Ae. aegypti mosquitoes at high rates but only the chimera containing viral genes encoding all of the structural proteins of ONNV was able to infect An. gambiae mosquitoes. These data indicate that all of the viral structural proteins are necessary for ONNV to infect An. gambiae mosquitoes.

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O'nyong-nyong fever: An epidemic virus disease in East Africa 1. Introduction

Cited by 79 publications

References 4 publications

An epidemic of oligoarticular arthritis in children and adults in three connecticut communities

An epidemic of oligoarticular arthritis in children and adults in three connecticut communities

The Role of Innate versus Adaptive Immune Responses in a Mouse Model of O'Nyong-Nyong Virus Infection

Determinants of Vector Specificity of O’nyong Nyong and Chikungunya Viruses in Anopheles and Aedes Mosquitoes

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