O-Glycosylating Enzyme GALNT2 Predicts Worse Prognosis in Cervical Cancer

Zhou, Lixia; Wu, Huiqin; Bai, Xiangzhi; Min, Shuyun; Zhang, Jiawen; Li, Cunli

doi:10.3389/pore.2022.1610554

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The biological role of CXCL6 in CC is to promote tumor growth, metastasis, and aggressiveness [79]. Moreover, the co-expression of a glycosylating enzyme, GALNT2, and CXCL6 indicates poor overall survival of the disease [80].…”

Section: Discussionmentioning

confidence: 99%

The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation

Fernandez-Avila,

Castro-Amaya,

Molina-Pineda

et al. 2023

Biomedicines

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Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis. In cancer, chemokine ligands and receptors are involved in tumor cell growth, metastasis, leukocyte infiltration, and angiogenesis; however, information on the role played by E6/E7 of HPV16/18 in the modulation of chemokines is very limited. Therefore, this study aimed to determine whether chemokines are differentially expressed in CC-derived cell lines; if E6/E7 oncoproteins from HPV16 and 18 are capable of mediating chemokine expression, what is the expression profile of chemokines in tissues derived from CC and what is their impact on the overall survival of patients with this pathology? For this purpose, RNA sequencing and real-time PCR were performed on SiHa, HeLa, and C33A tumorigenic cell lines, on the non-tumorigenic HaCaT cells, and the E6/E7 HPV-transduced HaCaT cell models. Furthermore, chemokine expression and survival analysis were executed on 304 CC and 22 normal tissue samples from The Cancer Genome Atlas (TCGA) repository. The results demonstrate that CXCL1, CXCL2, CXCL3, and CXCL8 are regulated by E6/E7 of HPV16 and 18, are overexpressed in CC biopsies, and that their higher expression is related to a worse prognostic survival.

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Section: Discussionmentioning

confidence: 99%

The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation

Fernandez-Avila,

Castro-Amaya,

Molina-Pineda

et al. 2023

Biomedicines

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Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker

Wang,

Luo,

et al. 2023

Glycoconj J

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This study investigates the potential role of Glycosyltransferases (GTs) in the glycosylation process and their association with malignant tumors. Specifically, the study focuses on PARP14, a member of GTs, and its potential as a target for tumors in the diagnosis and treatment of cervical cancer. To gather data, the study used somatic mutation data, gene expression data and clinical information from TCGA-CESE dataset as well as tissue samples from cervical cancer patients. Further verification was conducted through RT-qPCR and immunohistochemistry staining on cervical cancer tissues to confirm the expression of PARP14. The study utilized Kaplan-Meier for survival analysis of cervical cancer patient and found significant mutational abnormalities in GTs. The high frequency mutated gene was identified as PARP14. RT-qPCR revealed significantly higher mRNA expression of PARP14 compared to precancerous tissue. Using IHC combined with Kaplan-Meier,patients in the PARP14 high expression group had a better prognosis than the low expression group. The study identified PARP14 as a frequently mutated gene in cervical cancer and proposed its potential role in diagnosis and treatment.

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The sub-molecular characterization identification for cervical cancer

Wang²,

He³

et al. 2023

Heliyon

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O-Glycosylating Enzyme GALNT2 Predicts Worse Prognosis in Cervical Cancer

Cited by 3 publications

References 36 publications

The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation

The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation

Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker

The sub-molecular characterization identification for cervical cancer

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