O-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness

Chen, Yifan; Liu, Ji Guang; Zhang, Wentao; Kadier, Aimaitiaji; Wang, Ruiliang; Zhang, Haimin; Yao, Xudong

doi:10.2147/ott.s258175

Cited by 15 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, we found that O-GlcNAcylation also stabilized the proteins in the spliceosome ( Figure 6C ). The majority of O-GlcNAcylated proteins quantified in the nucleolus have longer half-lives than the corresponding non-modified ones, which is consistent with previous reports about some nucleolar proteins being stabilized by O-GlcNAcylation ( Chen et al, 2021 ). O-GlcNAcylation extensively modifies histone “writers” and “erasers” to modulate their activities, and one critical means is by mediating the protein stability.…”

Section: Resultssupporting

confidence: 91%

“…Since its discovery, O-GlcNAcylation has attracted great attention due to its importance in biological systems, including the regulation of gene expression and signal transduction ( Hart et al, 2011 ; Torres and Hart, 1984 ; van der Laarse et al, 2018 ). Aberrant protein O-GlcNAcylation is directly related to multiple human diseases, such as diabetes and cancer ( Chen et al, 2021 ; de Queiroz et al, 2016 ; Hart et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spatial and temporal proteomics reveals the distinct distributions and dynamics of O-GlcNAcylated proteins

Tong

Suttapitugsakul

et al. 2022

Cell Reports

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Spatial and temporal proteomics reveals the distinct distributions and dynamics of O-GlcNAcylated proteins

Tong

Suttapitugsakul

et al. 2022

Cell Reports

View full text Add to dashboard Cite

“…Jin et al (Jin et al 2020a ) revealed that hyper- O -GlcNAcylation can promote the malignant phenotype of BC cells, while knockdown of OGT could reverse these effects. Recently, Chen et al (Chen et al 2021 ) reported similar results: Inhibiting OGT led to downregulation of the cell cycle-related protein nucleolar and spindle associated protein 1 (NUSAP1), thereby inhibiting the malignant progression of BC. Melatonin has previously been shown to inhibit the growth of BC (Reiter et al 2017 ).…”

Section: O -Glcnac and Cancermentioning

confidence: 81%

O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Zhang

Liang

et al. 2022

Mol Med

View full text Add to dashboard Cite

O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants. In eukaryotes, only two conserved enzymes are involved in this process. O-GlcNAc transferase is responsible for adding O-GlcNAc to proteins, while O-GlcNAcase is responsible for removing it. Aberrant O-GlcNAcylation is associated with a variety of human diseases, such as diabetes, cancer, neurodegenerative diseases, and cardiovascular diseases. Numerous studies have confirmed that O-GlcNAcylation is involved in the occurrence and progression of cancers in multiple systems throughout the body. It is also involved in regulating multiple cancer hallmarks, such as metabolic reprogramming, proliferation, invasion, metastasis, and angiogenesis. In this review, we first describe the process of O-GlcNAcylation and the structure and function of O-GlcNAc cycling enzymes. In addition, we detail the occurrence of O-GlcNAc in various cancers and the role it plays. Finally, we discuss the potential of O-GlcNAc as a promising biomarker and novel therapeutic target for cancer diagnosis, treatment, and prognosis.

show abstract

“…Low expression of OGT was associated with prognosis in the endometrium tumor (P = 1.6616E-06). OGT were reported that it is overactivated in many kinds of cancers and is involved in the advanced progression of cancer 19 , the increase of O-GlcNAc modi cation of cell protein is a common feature of tumor cells, and the glycosylation level of O-GlcNAc in tumor cells with higher deterioration degree is higher 20 , and stably interacts with and modi es all three TET proteins,and help produce TET to form O-GlcNAcylated TET and can also interact with TET to form a complex with the ability to further modify chromatin which participated in controlling embryonic development and cancer progression 21 , OGT is highly dependent on glucose and this modi cation generally becomes more abundant in various metabolic pathways in cancer cells 22 . OGT controls ovarian cancer cell motility through the RhoA/ROCK signal pathway 23 .…”

Section: Discussionmentioning

confidence: 99%

Relationship between insulin resistance and endometrial cancer was revealed by gene screening

Ding

Zhou²,

He³

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Epidemiological studies have found, the occurrence of endometrial cancer (EC) is closely related to metabolic diseases, and insulin resistance (IR) plays an important role in the pathogenesis of endometrium, but the specific pathogenesis is still unclear. The purpose of this study is to reveal the relationship between insulin resistance and endometrial carcinoma. Methods: We analyzed one endometrial carcinoma database (GSE106191) and one insulin-resistant database (GSE63992), with GEO database and Venny online analysis tool, and P-value< 0.05 was thought about as statistically significant, then, we found an add-up to 148 different genes. Functional enrichment analysis of these genes using DAVID showed that they were participated in transcription factor activity, signaling pathways and response to factors, etc. Then used Cytoscape to establish Protein-Protein Interaction network, and got 25 hub genes. Then further analyzed the expression differences, histological differences, survival analysis, immune infiltration and genetic alteration of 25 hub genes.Results: Of the 25 hub genes, 9 hub genes (KLF5, BRD4, E2F2, LYN, HES1, YY1, IGSF3, TRAF3 and GJB3) were over-expressed in endometrial carcinoma, 11hub genes (TRO, NEURL2, PTEN, RARA, RYBP, OGT, FBXW7, PIK3C3, PIK3C2B, ING3 and DDX58) were under-expressed, and there were no significant difference among 5 hub genes (MYL12A, RAD21, TGFBRAP1, IRAK2 and PTPN1).The results showed that the survival time of patients expressing OGT, IGSF3, TRO, NEURL2 and PIK3C2B may be significantly and closely related to EC, and the percentage of gene changes of five central genes ranged from 3% to 10% of a single gene, was also related to the infiltration of seven kinds of immune cells in endometrial carcinoma.Conclusion: The five key genes (OGT, IGSF3, PIK3C2B, TRO and NEURL2) may be involved in immune infiltration in the progression of endometrial carcinoma, and there is also a certain mutation probability in gene mutation. Insulin resistance may be a trigger in the pathogenesis of endometrial cancer.

show abstract

O-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness

Cited by 15 publications

References 29 publications

Spatial and temporal proteomics reveals the distinct distributions and dynamics of O-GlcNAcylated proteins

Spatial and temporal proteomics reveals the distinct distributions and dynamics of O-GlcNAcylated proteins

O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Relationship between insulin resistance and endometrial cancer was revealed by gene screening

Contact Info

Product

Resources

About