“…The importance of the longer isoform of FAM134B to ER‐phagy has been demonstrated in both overexpression and knockout models. Overexpression of FAM134B results in increased fragmentation of the ER and enhanced ER‐phagy, as measured by increased degradation of ER‐resident proteins such as SEC61B or autophagy marker p62 (Bhaskara et al, 2019; Fregno et al, 2018; Jiang et al, 2020; Khaminets et al, 2015; Liang et al, 2018; Liao et al, 2019; Luo, Li, et al, 2022; Luo, Liang, et al, 2022). Conversely, decreasing FAM134B expression leads to expansion of the ER in knockdown experiments (Jiang et al, 2020; Khaminets et al, 2015; Kohno et al, 2019; Kurth et al, 2009; Lennemann & Coyne, 2017; Luo, Liang, et al, 2022; Reggio et al, 2021) and this expansion is also evident in FAM134B knockout mouse embryonic fibroblasts (Chiramel et al, 2016; Reggio et al, 2021).…”