Abstract:The accumulation of dysfunctional mitochondria is closely associated with Alzheimer Disease (AD). Mitochondrial dysfunction is an early feature of the disease and impaired turnover of damaged mitochondria increases cellular toxicity leading to neuronal damage. Importantly, AD exhibited a marked reduction in global post‐translational modification β‐N‐acetylglucosamine (O‐GlcNAc) level in post‐mortem human brain tissue with AD and triple transgenic mouse model of AD (3xTg‐AD). O‐GlcNAc is a ubiquitous single sug… Show more
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