O envolvimento do sistema Renina-Angiotensina nas disfunções cardiovasculares e seus recursos farmacológicos

Silva, Thiago Fernandes da; Vaz, Tânia; Souza, Miguel Soares de; Ferreira, Lívia Penna; Filho, Marcelo Limborço; Fontes, Marco Antônio Peliky; Marins, Fernanda Ribeiro

doi:10.32749/nucleodoconhecimento.com.br/saude/renina-angiotensina

Cited by 1 publication

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The regulation of blood pressure and homeostasis of the body also involves the activation of the renin-angiotensin system (RAS). The increase in sympathetic activity and changes in the concentration of vascular sodium chloride (NaCl) activate RAS, initially triggering the release of renin, an enzyme produced and stored by renal cells (Silva et al, 2019). The authors add that, when renin is converted into the bloodstream, it converts angiotensinogen, an alpha-2-globulin synthesized mainly in the liver, into angiotensin I (Ang I) which, due to the influence of the angiotensin-converting enzyme (ACE), protease found especially in the vascular endothelial cells of the lung, forms angiotensin II (Ang II).…”

Section: Cardiac Work In Systemic Arterial Hypertension (Sah)mentioning

confidence: 99%

“…The authors add that, when renin is converted into the bloodstream, it converts angiotensinogen, an alpha-2-globulin synthesized mainly in the liver, into angiotensin I (Ang I) which, due to the influence of the angiotensin-converting enzyme (ACE), protease found especially in the vascular endothelial cells of the lung, forms angiotensin II (Ang II). Ang II, according to Silva et al (2019), promotes actions locally, at tissue level or by transporting its components in the bloodstream, with vasoconstrictor, pro-oxidant and pro-inflammatory responses.…”

Section: Cardiac Work In Systemic Arterial Hypertension (Sah)mentioning

confidence: 99%

“…Under conditions of hyperactivity, RAS contributes significantly to a series of harmful events to the kidneys, vessels and heart, mainly associated with myocardial infarction, cardiac hypertrophy, atherosclerosis and heart failure (Silva et al, 2019;Queiroz, Calzerra & Gomes, 2018;Paul, Mehr & Kreutz, 2006). RAS hyperactivity can also cause vascular injury induced by vasoconstriction, proliferation and hypertrophy of smooth muscle cells and vascular inflammation with degradation of the cellular matrix (Queiroz, Calzerra & Gomes, 2018;Paul, Mehr & Kreutz, 2006).…”

Section: Cardiac Work In Systemic Arterial Hypertension (Sah)mentioning

confidence: 99%

See 2 more Smart Citations

Systemic arterial hypertension: treatment with Integrative and Complementary Health Practices

Pinheiro

Montes

Fraga

et al. 2020

RSD

View full text Add to dashboard Cite

Systemic Arterial Hypertension (SAH) can generate complications such as stroke, myocardial infarction, kidney disease, arteriosclerosis, loss of vision, erectile dysfunction and cognitive dysfunction. Among people who know they suffer from hypertension, 50% use medication and of those only 45% have their blood pressure kept under control. SAH is a multifactorial clinical condition characterized by elevated and sustained blood pressure levels (BP, where systolic BP ≥ 140 mmHg and diastolic BP ≥ 90 mmHg). Faced with sparse investigative studies on the causes of SAH in individuals, the dictates of the pharmaceutical industry and the use of in vitro or inconclusive clinical studies, this paper presents the state of the art about the treatment of SAH based on a multifaceted view, including aspects about the physiology of SAH, food and PANC as alternatives for the prevention and control of SAH, as well as an approach on the importance of scientific rigor in the manufacture of medicines.

show abstract

Section: Cardiac Work In Systemic Arterial Hypertension (Sah)mentioning

confidence: 99%

Section: Cardiac Work In Systemic Arterial Hypertension (Sah)mentioning

confidence: 99%