In this theoretical article, we discuss the ways of articulating Human Rights and the teaching of Natural Sciences in the early years of elementary school, in a perspective focused on the humane education. The theoretical basis for further discussion of the proposed subject matter was carried out through bibliographic research, having as sources: books, scientific articles and official documents. From this research, we proposed some topics that are related to human rights and are possible to be articulated with the contents of Natural Sciences developed in the early years. We consider that these topics need to be based on structuring axes that will base the pedagogical work of the teachers, so that they have as purpose the humane education of the students. These axes are: to become aware of the recognition of social, cultural and economic differences; to recognize oneself as a citizen with rights and to respect the right of the other; to plan and develop inclusive practices; to value the interrelationship between human beings and natural environments. We consider that the pedagogical work aimed at this perspective needs to be based on a dialogical and participatory methodology, with an emphasis on a humane and socially responsible education.