O analiză intermediară a formelor medii şi severe de COVID-19 tratate în Clinica de Boli Infecţioase Craiova

Giubelan, Lucian; Dragonu, Livia; Stoian, Andreea Cristina; Dumitrescu, Florentina

doi:10.37897/rjid.2020.4.4

Cited by 3 publications

(2 citation statements)

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“…In the USA, viscoelastometric test training is recommended for general surgery residents, and a further expansion of this method is expected in the near future [ 17 ]. Significant differences in the levels of inflammatory biomarkers and metabolic parameters in moderate or severe COVID-19 patients (with diabetes/obesity) have been described: in contrast to infected subjects without these comorbidities, the diabetic/obese patients with severe COVID-19 presented a significantly increased leukocyte count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-dimers, and serum glucose concentration [ 18 ]. A comprehensive study performed in Romania revealed that elevated inflammatory markers were independent predictors of poor outcomes for all SARS-CoV-2-infected patients.…”

Section: Introductionmentioning

confidence: 99%

The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases

Szilveszter¹,

Pál

Simon-Szabó

et al. 2023

IJMS

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The course of COVID-19 is highly dependent on the associated cardiometabolic comorbidities of the patient, which worsen the prognosis of coronavirus infection, mainly due to systemic inflammation, endothelium dysfunction, and thrombosis. A search on the recent medical literature was performed in five languages, using the PubMed, Embase, Cochrane, and Google Scholar databases, for the review of data regarding the management of patients with a high risk for severe COVID-19, focusing on the associated coagulopathy. Special features of COVID-19 management are presented, based on the underlying conditions (obesity, diabetes mellitus, and cardiovascular diseases), emphasizing the necessity of a modern, holistic approach to thromboembolic states. The latest findings regarding the most efficient therapeutic approaches are included in the article, offering guidance for medical professionals in severe, complicated cases of SARS-CoV-2 infection. We can conclude that severe COVID-19 is closely related to vascular inflammation and intense cytokine release leading to hemostasis disorders. Overweight, hyperglycemia, cardiovascular diseases, and old age are important risk factors for severe outcomes of coronavirus infection, involving a hypercoagulable state. Early diagnosis and proper therapy in complicated SARS-CoV-2-infected cases could reduce mortality and the need for intensive care during hospitalization in patients with cardiometabolic comorbidities.

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Section: Introductionmentioning

confidence: 99%

The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases

Szilveszter¹,

Pál

Simon-Szabó

et al. 2023

IJMS

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“…All clinical forms of anthrax require the administration of antibiotic treatment, the combination of monoclonal antibodies being recommended in inhaled anthrax [ 4 , 6 ]. From a surgical point of view, in the uncomplicated cutaneous anthrax, a conservative attitude is recommended because the surgical intervention in the acute period can determine a possible bacteremia [ 4 , 6 ]. However, treatment decisions must be made on the basis of the individual presentation of each case [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Human Anthrax in Dolj County, Romania—A Series of Three Cases

et al. 2021

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Bacillus anthracis is the causative agent of anthrax, primarily a disease of herbivorous animals, which can be accidentally transmitted to humans. Three cases of cutaneous human anthrax were recorded in August 2020 in Dolj county, Romania. These cases included livestock farmers (husband and wife, as well as a man from their entourage). The women presented malignant edema, which required surgery for compartment syndrome; and the men presented the common form of cutaneous anthrax. According to the laboratory investigation, two cases complied with the criteria in the case definition. All cases were successfully treated with antibiotics and the women received reconstructive plastic surgery of the skin defects, restoring normal hand function. The contact with sick animals was ruled out by the health authorities concluding that it was the contamination of pre-existing skin lesions with B. anthracis spores from the soil, the anthracogenic area.

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Systemic inflammation and quality of life in patients with coronavirus disease: interrelation features

Pavlovskyi,

Vozniuk

2024

Wiad Lek

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Aim: To characterize the features of the interrelation of systemic inflammation with the quality of life of patients with coronary virus disease. Materials and Methods: 30 patients were examined 1 month after inpatient treatment for COVID-19. Quality of life (QoL) of patients was determined according to the questionnaire Medical Outcomes Study – 36-item Short Form (SF-36). The glucose level, circulating immune complexes (CICs), concentration of immunoglobulin (Ig) A, interleukin (IL)-8 and IL-33 levels were determined in the blood serum of patients. Results: QoL of patients after coronavirus disease is significantly deteriorated: patients note a significant limitation in physical functioning, pain perception, vitality, role-physical and social functioning and mental health. The increase in glycemia and glycated hemoglobin levels in post-COVID-19 patients was significantly associated with the deterioration of patients` general health (GH) (r = −0,228; (p=0,040) and (r = −0,280; (p=0,014), respectively). The IL-33 concentration in such patients correlated directly with role-physical functioning (RP) (r = 0,385; p=0,029). The CICs level decline was associated with deterioration of RP (r = 0,227; p=0,042) and GH (r = 0,227; p=0,041). Conclusions: The study of clinical-functional, biochemical, immunological and psychological indicators, quality of life, and their mutual influences should be included in the development of the program for the diagnosis, treatment, and rehabilitation of patients after the transfer of COVID-19 at the outpatient stage of treatment by doctors of general practice-family medicine.

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O analiză intermediară a formelor medii şi severe de COVID-19 tratate în Clinica de Boli Infecţioase Craiova

Cited by 3 publications

References 0 publications

The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases

The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases

Human Anthrax in Dolj County, Romania—A Series of Three Cases

Systemic inflammation and quality of life in patients with coronavirus disease: interrelation features

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