O▪78 Turkey▪s experience of PGD of single gene disorders

Preimplantation HLA Typing

“…HLA typing without mutation analysis has also been used for acquired diseases , such as acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), which require allogenic haemopoietic stem cell transplantation (HSCT) from an HLA identical donor for the cure of the disease. Stem cells in the cord blood from an HLA identical sibling can be used with a much higher success rate than a transplant from alternative donors (Gaziev et al, 2000;Orofino et al, 2003) and are therefore of great therapeutic value for hematopoietic and other life-threatening diseases (Fiorentino et al, 2006;Kahraman et al, 2004Kahraman et al, , 2007Verlinsky et al, 2001Verlinsky et al, , 2004Van de Velde et al, 2004. In particular for blood-borne disorders, hematopoietic stem cells (HSC) from HLA-identical siblings provide the highest success rate and current results indicate that about 90% of the cases can be cured successfully after HSC transplantation (Gaziev et al, 2005).…”