Abstract:Insulin controls cell metabolism and proliferation through several diverging pathways which are only partially understood. One important metabolic effect is to antagonize hormone-activated lipolysis in adipose tissue, brought about mainly via insulin-mediated activation of a membrane-associated cGMP-inhibited phosphodiesterase [cGI PDE] which leads to a reduction in cAMP, a decrease in cAMP dependent protein kinase (A-kinase) activity and a lowering of the phosphorylation and thereby the activity of the hormon… Show more
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