O.21 Cytokine levels in critically-ill septic patients fed with an enteral diet supplemented with fish oil and vitamin E

Garmendia, J.L. García; Montero, Jennifer; Leyba, C. Ortiz; Jiménez, F. J. Jiménez; Estad, M.R. Moyano del; Villar, Jesús Monterrubio; Paredes, Jasmine

doi:10.1016/s0261-5614(98)80089-7

Cited by 3 publications

(3 citation statements)

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“…IL-6 and IL-10 are supposed to be indicators of the systemic inflammatory response in AP. 10 Increased IL-10 production under fish oil supplementation has also been reported by other groups, eg, by Garcia-Gamendia et al, 34 who found that fish oil (and vitamin E) significantly increased IL-10 plasma levels in septic patients. The difference in IL-6 levels did not reach statistical significance in the presence of high SDs.…”

Section: November-december 2002supporting

confidence: 53%

Omega‐3 fatty acid supplementation increases anti‐inflammatory cytokines and attenuates systemic disease sequelae in experimental pancreatitis

Foitzik¹,

Eibl²,

Schneider³

et al. 2002

J Parenter Enteral Nutr

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Section: November-december 2002supporting

confidence: 53%

Omega‐3 fatty acid supplementation increases anti‐inflammatory cytokines and attenuates systemic disease sequelae in experimental pancreatitis

Foitzik¹,

Eibl²,

Schneider³

et al. 2002

J Parenter Enteral Nutr

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“…It has been shown that it could be down-regulated by the over expression of TNF and other inflammatory cytokines from activated macrophages. Animal experiments have demonstrated that IL-10 could block the release of oxygen free radicals and nitrogen oxide in acute pancreatitis [25][26][27][28]. Anthony JR et al found in acute pancreatitis model of rats that IL-10 could ameliorate the systemic sequelae of acute pancreatitis, in consequence, it could decrease the mortality [25].…”

Section: Discussionmentioning

confidence: 99%

“…Animal experiments have demonstrated that IL-10 could block the release of oxygen free radicals and nitrogen oxide in acute pancreatitis [25][26][27][28]. Anthony JR et al found in acute pancreatitis model of rats that IL-10 could ameliorate the systemic sequelae of acute pancreatitis, in consequence, it could decrease the mortality [25]. In this study, the plasma concentration of IL-10 increased in SAP patients after ω−3 FAs supplemented PN, while it decreased in the ω−6 FAs group.…”

Section: Discussionmentioning

confidence: 99%

Fish Oil-Supplemented Parenteral Nutrition in Severe Acute Pancreatitis Patients and Effects on Immune Function and Infectious Risk: A Randomized Controlled Trial

Wang

Zhang

et al. 2009

Inflammation

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The human leukocyte antigen (HLA)-DR expression on monocytes and plasma Interleukin (IL)-10 levels are key indicators of immune response during the acute phase of severe acute pancreatitis (SAP). We designed a pilot study to investigate whether omega-3 fatty acids (FAs) supplemented parenteral nutrition (PN) could improve immune response in SAP patients. Fifty-six SAP patients were enrolled (28 patients in each group) and received isocaloric and isonitrogenous parenteral nutrition, providing 1.0 g/kg/day standard soybean-oil based fat (omega-6 FAs group) or 0.8 g/kg/day soybean oil +0.2 g/kg/day omega-3 FAs based fat (omega-3 FAs group). IL-10, HLA-DR and the ratio of CD4(+) to CD8(+) were determined before PN treatment and on day 6 after starting PN. The infection and surgery rates were recorded until hospital discharge. A significant IL-10 increase was associated with the administration of omega-3 FAs (p = 0.04, vs omega-6 FAs group). Monocyte HLA-DR expression improved in both groups after 5 days of PN treatment. This increase was significantly higher in the omega-3 FAs group compared to omega-6 FAs (p = 0.01). There was no significant difference of CD4(+)/CD8(+), infection and surgery rates between the two groups. In conclusion, omega-3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in SAP patients. A larger trial is required to see whether omega-3 FAs supplemented PN treatment in SAP patients would result in better clinical outcomes than omega-6 FAs.

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Current evidence on ω-3 fatty acids in enteral nutrition in the critically ill: A systematic review and meta-analysis

2019

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O.21 Cytokine levels in critically-ill septic patients fed with an enteral diet supplemented with fish oil and vitamin E

Cited by 3 publications

References 0 publications

Omega‐3 fatty acid supplementation increases anti‐inflammatory cytokines and attenuates systemic disease sequelae in experimental pancreatitis

Omega‐3 fatty acid supplementation increases anti‐inflammatory cytokines and attenuates systemic disease sequelae in experimental pancreatitis

Fish Oil-Supplemented Parenteral Nutrition in Severe Acute Pancreatitis Patients and Effects on Immune Function and Infectious Risk: A Randomized Controlled Trial

Current evidence on ω-3 fatty acids in enteral nutrition in the critically ill: A systematic review and meta-analysis

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