Epidemics have been one of the disasters that humanity has been most affected throughout history. These diseases, which have emerged in various parts of the history in many parts of the world, have caused thousands of people to die. As in the rest of the world, the Ottoman Empire was exposed to the devastating effects of epidemics. As a matter of fact, one of these diseases is cholera. It was first seen in the Ottoman lands in 1822 and spread through trade relations, migrations, wars and pilgrimage. Therefore, XIX. Cholera, which has become a global threat since the first quarter of the 18th century, has been one of the diseases that negatively affected the daily life of the Ottomans for a long time. Cholera disease, which occurs in many parts of Anatolia, has been effective in Izmir and its environs at different periods. As a matter of fact, the disease, which was effective in Izmir in the middle of 1893, became an epidemic especially in August and reached serious proportions. A significant number of those who were exposed to the epidemic until November of the same year died. In order to prevent the spread of the disease, the Ottoman Government first took a number of quarantine measures. Then, specialist doctors were brought and some precautions were taken about daily life. However, the disease that has appeared in Izmir has spread to some of the surrounding cities and towns, despite all the precautions taken, and has caused serious destruction in a few. In short, it has had significant socio-economic effects in and around Izmir. As a result, in this study, the development and effects of cholera which were effective in İzmir and its environs in 1893 and the measures taken by the state were tried to be put forward. While doing this, the Ottoman archive documents were taken as the basis, and the news about the epidemic in the press of Izmir and Istanbul were also included.