O.120 Bisphosphonate-vascular osteonecrosis of the jaws: Medical or surgical approach?

Rossi, R.V; D’Orto, Ornella; Agazzi, A.; Marzano, Umberto Giorgio; Troletti, G. Derada

doi:10.1016/s1010-5182(06)60149-2

Cited by 1 publication

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“…An analysis of these cases [28][29][30][31][32][33][34][35][36][37][38][39][40][41], including the current case, reveals a female predominance (206 women, 147 men), with a male-to-female ratio of 0.7:1. The (3) ABs; debridement (7) Breast carcinoma (1) ABs; maxillectomy (2) Lung carcinoma (4) Mandibular resection (1) Prostate carcinoma (2) Magopoulos [29] Breast carcinoma (18) HBO; ABs; surgery (6) ZA (33) Lung carcinoma (2) Cessation of BP; ABs (24) Prostate carcinoma (5) ABs (11) Neuroendocrine carcinoma (1) ABs; surgery (10) Fibrous dysplasia (1) Amyloidosis (1) Clarke [30] (1) Medical; surgical, not specified (10) ZA (5) Prostate carcinoma (1) Not specified (2) Metastatic lymphoma (1) No treatment (1) Osteoporosis (1) Mortensen [31] Risedronate (2) Osteoporosis (2) ABs; sequestrectomy (1) ABs (1) Rossi [32] Prostate carcinoma (2) Medical …”

Section: Discussionmentioning

confidence: 99%

“…The (3) ABs; debridement (7) Breast carcinoma (1) ABs; maxillectomy (2) Lung carcinoma (4) Mandibular resection (1) Prostate carcinoma (2) Magopoulos [29] Breast carcinoma (18) HBO; ABs; surgery (6) ZA (33) Lung carcinoma (2) Cessation of BP; ABs (24) Prostate carcinoma (5) ABs (11) Neuroendocrine carcinoma (1) ABs; surgery (10) Fibrous dysplasia (1) Amyloidosis (1) Clarke [30] (1) Medical; surgical, not specified (10) ZA (5) Prostate carcinoma (1) Not specified (2) Metastatic lymphoma (1) No treatment (1) Osteoporosis (1) Mortensen [31] Risedronate (2) Osteoporosis (2) ABs; sequestrectomy (1) ABs (1) Rossi [32] Prostate carcinoma (2) Medical (2) Osteoporosis (1) Neuroendocrine carcinoma (1) Fibrous dysplasia (1) (6) Breast carcinoma (10) ZA (9) Prostate carcinoma (1) Bagan [36] Breast carcinoma (6) ZA (2) Cheng [11] Debridement (1) Not specified…”

Section: Discussionmentioning

confidence: 99%

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Bisphosphonate-induced Osteonecrosis of the Jaws: Review, Clinical Implications and Case Report

Suleman

Meer

Lurie

2007

Head and Neck Pathol

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The introduction of bisphosphonates has increased in the last decade following their indication for metastatic bone diseases, osteoporosis, hypercalcaemia of malignancy and Paget's disease. Although bisphosphonates have been used clinically for more than three decades there have been no documented long-term complications of their effects on the jaws until recently, where there is now growing evidence of the influence of bisphosphonates on osteonecrosis of the jaws. The aim of this paper is to report a case of this newly described complication, to review this phenomenon, including the clinical implications and to reiterate current clinical guidelines for management of patients in which bisphosphonate therapy is indicated. To the best of our knowledge this is the first reported case of bisphosphonate-induced necrosis of the jaw in South Africa.

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